Research ArticleALLERGY

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma

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Science Translational Medicine  26 Oct 2016:
Vol. 8, Issue 362, pp. 362ra143
DOI: 10.1126/scitranslmed.aaf8807

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Airway allergy alleviated by hookworm protein

One reason for allergy prevalence in the developed world may be a lack of exposure to parasites, which can influence immune development and function. Because administering live parasites to people might pose safety issues, Navarro et al. tested the ability of the hookworm protein AIP-2 to treat airway allergic sensitization. Administration of AIP-2 could prevent or treat asthma symptoms in a mouse model, in a mechanism that was dependent on dendritic cells and regulatory T cells. Encouragingly, AIP-2 also reduced activation of human dendritic cells and T cells, indicating that these findings may readily translate to the clinic.