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Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

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Science Translational Medicine  26 Oct 2016:
Vol. 8, Issue 362, pp. 362ps17
DOI: 10.1126/scitranslmed.aaf9246

Article Information

vol. 8 no. 362 362ps17

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Author Information

  1. Yves Pommier1,*,
  2. Mark J. O’Connor2 and
  3. Johann de Bono3
  1. 1Laboratory of Molecular Pharmacology and Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  2. 2DNA Damage Response Biology, Oncology IMED, AstraZeneca, Hodgkin Building, B900 Chesterford Research Park, Little Chesterford, Cambridge CB10 1XL, U.K.
  3. 3Drug Development Unit, Institute of Cancer Research and Royal Marsden National Health Service Foundation Trust, London SM2 5PT, U.K.
  1. *Corresponding author. Email: pommier{at}nih.gov

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