Contents
26 October 2016
Vol 8, Issue 362
Vol 8, Issue 362
Contents
Perspective
- Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action
Understanding the mechanism of action of PARP inhibitors is key to optimizing their clinical use and effectiveness.
Research Articles
- The neural basis of perceived intensity in natural and artificial touch
Electrical connections between nerves and a prosthetic device enable amputees to discern precise, graded sensory intensity ranging from light touch to intense pressure.
- Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma
A secreted hookworm protein in recombinant form acts on dendritic cells to drive the expansion and mucosal homing of regulatory T cells that protect against airway inflammation in mice, and also dampens human dendritic cell and T cell activation.
- Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy
Senescent cells encourage abnormal blood vessels and retinal disease.
- A replication-defective human cytomegalovirus vaccine for prevention of congenital infection
A new replication-defective human cytomegalovirus vaccine shows promise in protecting against this dangerous virus that can cause severe neurodevelopmental defects in babies.
- Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease
The approved drug NDP-MSH ameliorates neurodegeneration in mouse models of neuroinflammatory disease.
Editors' Choice
- A twist of fat(e): Liposuction to treat vascular disease
Human adipose–derived stem cells produce tissue-engineered blood vessels with robust material properties and an intact endothelial lining to prevent thrombosis.
- Resolvin’ inflammation
Plaque progression was halted by inducing inflammation resolution in the blood vessel walls of a mouse model of atherosclerosis with the preresolving lipid mediator RvD1.
- Hacking T cells with synthetic circuits to program antitumor responses
T cells are engineered to activate modular, user-specified antitumor programs in response to defined antigens.
About The Cover
ONLINE COVER Artificially Tickling the Ivories. This image shows two hands playing the piano. The natural hand has the ability to sense delicate changes in pressure in order to know how much force to apply on the keys, but the artificial hand does not. Applying variable pressure is a challenge for arm amputees because current neuroprosthetics lack the sense of touch. Graczyk et al. studied two upper-limb amputees implanted with electrodes in order to understand how the number and frequency of nerve firings contributed to perception of pressure intensity. [CREDIT: KENZIE GREEN]