Research ArticleMUSCLE DEGENERATION

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

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Science Translational Medicine  19 Oct 2016:
Vol. 8, Issue 361, pp. 361ra139
DOI: 10.1126/scitranslmed.aaf5504

Article Information

vol. 8 no. 361 361ra139

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 26, 2016
  • Accepted for publication September 12, 2016
  • .

Author Information

  1. Dongryeol Ryu1,*,
  2. Hongbo Zhang1,*,
  3. Eduardo R. Ropelle1,2,*,
  4. Vincenzo Sorrentino1,
  5. Davi A. G. Mázala3,
  6. Laurent Mouchiroud1,
  7. Philip L. Marshall4,
  8. Matthew D. Campbell5,
  9. Amir Safi Ali5,
  10. Gary M. Knowels5,
  11. Stéphanie Bellemin6,
  12. Shama R. Iyer7,
  13. Xu Wang1,
  14. Karim Gariani1,
  15. Anthony A. Sauve8,
  16. Carles Cantó9,
  17. Kevin E. Conley5,
  18. Ludivine Walter6,
  19. Richard M. Lovering7,
  20. Eva R. Chin3,,
  21. Bernard J. Jasmin10,
  22. David J. Marcinek5,
  23. Keir J. Menzies1,4, and
  24. Johan Auwerx1,
  1. 1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
  2. 2Laboratory of Molecular Biology of Exercise, School of Applied Science, University of Campinas, CEP 13484-350 Limeira, São Paulo, Brazil.
  3. 3Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742, USA.
  4. 4Interdisciplinary School of Health Sciences, University of Ottawa Brain and Mind Research Institute and Centre for Neuromuscular Disease, Ottawa, Ontario K1H 8M5, Canada.
  5. 5Department of Radiology, University of Washington, Seattle, WA 98195, USA.
  6. 6Centre de Génétique et de Physiologie Moléculaires et Cellulaires, Université Claude Bernard Lyon 1, CNRS UMR 5534, 69622 Villeurbanne, France.
  7. 7Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  8. 8Department of Pharmacology, Weill Cornell Medical School, New York, NY 10065, USA.
  9. 9Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland.
  10. 10Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
  1. Corresponding author. Email: admin.auwerx{at}epfl.ch (J.A.); kmenzies{at}uottawa.ca (K.J.M.)
    • * These authors contributed equally to this work.

    • Present address: Cytokinetics Inc., South San Francisco, CA 94080, USA.

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