19 October 2016
Vol 8, Issue 361
  • Contents

    • Editorial

    • Research Articles

      • Autoimmune manifestations in aged mice arise from early-life immune dysregulation

        Autoimmune manifestations are driven by peripheral immune dysregulation in early life and are prevented by prophylactic targeting of the CD40/CD40L pathway.

      • Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

        Treatment with DNase I–coated nanoparticles prevents metastasis by targeting neutrophil extracellular traps induced by cancer cells in a mouse model.

      • NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

        NAD+ treatment can reverse the functional decline in degenerating muscles.

      • Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

        A small molecule specifically kills cancer cells with APC truncations and spares cells with wild-type APC.

      • Intracortical microstimulation of human somatosensory cortex

        Tactile percepts were consistently elicited in the hand of a person with cervical spinal cord injury using intracortical microstimulation of the somatosensory cortex.

    • Editors' Choice

      • Lather, rinse, repeat for giant results

        Reusable giant magnetoresistive nanosensors with in situ synthesized peptides offer high-throughput and sensitive detection of autoantibodies.

      • New genetic insights into brain size

        A meta-analysis of large-scale human neuroimaging data reveals new genetic loci underlying brain volume.

      • Don’t mix zinc lozenges and antibiotics

        Dietary zinc increases susceptibility to Clostridium difficile infection following antibiotic use in mice.

      • The inflammasome keeps on breaking your heart

        A polymorphism that potentiates inflammasome activation results in a more aggressive course of Kawasaki disease in children.

      • Protecting kids with a patch

        A needle-free skin patch protects against respiratory syncytial virus via a TH1/TH17 immune response.

About The Cover

Cover image expansion

ONLINE COVER To NET or Not to NET. This image depicts two neutrophils, one of which is forming a DNA mesh called a neutrophil extracellular trap (NET) after being cultured together with cancer cells. Although NETs are usually generated in response to infection, Park et al. found that their production can also be stimulated by cancer cells, promoting metastasis. [CREDIT: L. MAIORINO AND S. HEARN/COLD SPRING HARBOR LABORATORY]