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Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

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Science Translational Medicine  12 Oct 2016:
Vol. 8, Issue 360, pp. 360ra135
DOI: 10.1126/scitranslmed.aaf5219

Article Information

vol. 8 no. 360 360ra135

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 25, 2016
  • Accepted for publication September 13, 2016
  • .

Author Information

  1. Nuh N. Rahbari1,2,*,
  2. Dmitriy Kedrin1,3,
  3. Joao Incio1,
  4. Hao Liu1,
  5. William W. Ho1,4,
  6. Hadi T. Nia1,
  7. Christina M. Edrich1,
  8. Keehoon Jung1,
  9. Julien Daubriac1,
  10. Ivy Chen1,5,
  11. Takahiro Heishi1,
  12. John D. Martin1,
  13. Yuhui Huang1,,
  14. Nir Maimon1,
  15. Christoph Reissfelder2,
  16. Jurgen Weitz2,
  17. Yves Boucher1,
  18. Jeffrey W. Clark6,
  19. Alan J. Grodzinsky7,
  20. Dan G. Duda1,
  21. Rakesh K. Jain1, and
  22. Dai Fukumura1,
  1. 1Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  2. 2Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden 01307, Germany.
  3. 3Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  4. 4Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  5. 5Harvard School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  6. 6Department of Hematology/Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  7. 7Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  1. Corresponding author. Email: dai{at}steele.mgh.harvard.edu (D.F.); jain{at}steele.mgh.harvard.edu (R.K.J.)
  • * Present address: Surgical Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

  • Present address: Cyrus Tang Hematology Center, Soochow University, Jiangsu, 215123, China.

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