Research ArticleSICKLE CELL DISEASE

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

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Science Translational Medicine  12 Oct 2016:
Vol. 8, Issue 360, pp. 360ra134
DOI: 10.1126/scitranslmed.aaf9336

Article Information

vol. 8 no. 360 360ra134

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 21, 2016
  • Accepted for publication September 22, 2016
  • .

Author Information

  1. Mark A. DeWitt1,2,
  2. Wendy Magis3,
  3. Nicolas L. Bray1,2,
  4. Tianjiao Wang1,2,
  5. Jennifer R. Berman4,
  6. Fabrizia Urbinati5,
  7. Seok-Jin Heo3,
  8. Therese Mitros2,
  9. Denise P. Muñoz3,
  10. Dario Boffelli3,
  11. Donald B. Kohn5,
  12. Mark C. Walters3,6,
  13. Dana Carroll1,7,*,
  14. David I. K. Martin3,* and
  15. Jacob E. Corn1,2,*
  1. 1Innovative Genomics Initiative, University of California, Berkeley, Berkeley, CA 94720, USA.
  2. 2Department of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
  3. 3Children’s Hospital Oakland Research Institute, University of California San Francisco (UCSF) Benioff Children’s Hospital, Oakland, CA 94609, USA.
  4. 4Digital Biology Center, Bio-Rad Laboratories, Pleasanton, CA 94588, USA.
  5. 5Departments of Microbiology, Immunology, and Molecular Genetics; Pediatrics; and Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  6. 6Blood and Marrow Transplant Program, Division of Hematology, UCSF Benioff Children’s Hospital, Oakland, CA 94609, USA.
  7. 7Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
  1. *Corresponding author. Email: jcorn{at}berkeley.edu (J.E.C.); dimartin{at}chori.org (D.I.M.); dana{at}biochem.utah.edu (D.C.)

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