12 October 2016
Vol 8, Issue 360

About The Cover

Cover image expansion

ONLINE COVER A Vascular Threat. This image depicts abnormal blood vessels in a mouse model of colorectal cancer liver metastasis, visualized by optical frequency domain imaging. A study by Rahbari et al. demonstrates that in addition to inhibiting blood vessel growth, antiangiogenic treatment of colorectal cancer increases tumors' stiffness, which presents a barrier for subsequent chemotherapy treatments. [CREDIT: N. RAHBARI, N. MAIMON, AND G. SEANO/MASSACHUSETTS GENERAL HOSPITAL RESEARCH INSTITUTE]