Contents
12 October 2016
Vol 8, Issue 360
Vol 8, Issue 360
Contents
Research Articles
- Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells
Hematopoietic stem cells from patients with sickle cell disease can be edited by CRISPR/Cas9 and maintain the edits in vivo.
- Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases
Anti-VEGF therapy enhances mechanical barriers to therapy in colorectal cancer liver metastases by increasing hyaluronan deposition.
- Preclinical and clinical assessment of inhaled levodopa for OFF episodes in Parkinson’s disease
A levodopa powder delivered by a breath-actuated inhaler produced a rapid increase in plasma drug concentrations and improved motor function during OFF episodes in patients with Parkinson’s disease.
Editors' Choice
- Peering inside the mind: Imaging brain activity with advanced diffuse optical tomography
An advance in diffuse optical tomography enables three-dimensional imaging of brain activity
- A new way to beat the heat
Specific neurons in the hypothalamus regulate body temperature and are rapidly activated by warmth.
- SNAPPy solution for fighting drug-resistant bacteria
Peptide polymer nanoparticles disrupt the outer membrane of Gram-negative bacteria and serve as broad-spectrum antimicrobials.
About The Cover
ONLINE COVER A Vascular Threat. This image depicts abnormal blood vessels in a mouse model of colorectal cancer liver metastasis, visualized by optical frequency domain imaging. A study by Rahbari et al. demonstrates that in addition to inhibiting blood vessel growth, antiangiogenic treatment of colorectal cancer increases tumors' stiffness, which presents a barrier for subsequent chemotherapy treatments. [CREDIT: N. RAHBARI, N. MAIMON, AND G. SEANO/MASSACHUSETTS GENERAL HOSPITAL RESEARCH INSTITUTE]