Contents
05 October 2016
Vol 8, Issue 359
Vol 8, Issue 359
Contents
Research Articles
- Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia
An in vitro drug screening using primary AML samples identified homoharringtonine (omacetaxine mepesuccinate) as an effective adjunct for treatment of FLT3-ITD AML.
- Mechanistic modeling of hemoglobin glycation and red blood cell kinetics enables personalized diabetes monitoring
On the basis of first principles, a model of hemoglobin glycation yields a personalized, more accurate estimate of average glucose for diabetics.
- Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo
A birefringence microscopy technique provides structural and functional information about airway smooth muscle in healthy and mild asthmatic subjects.
- Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation
The development of allergic asthma requires type 2 airway inflammation as well as increased sensitivity of airway epithelial cells and smooth muscle to inflammation.
Editors' Choice
- How to make a cocktail
Systematic drug screening informs higher-order drug combinations in cancer.
- The genetics of happiness
A genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs.
- Working for Tip(DC)s
Adoptive T cell therapy depends on induction of Tip-DCs, which promote T cell function and enhance tumor control.
- A basic strategy for detecting CD8 T cell specificity
Bentzen and colleagues develop DNA-barcoded peptide-MHC multimers to enable massively parallel profiling of the peptides recognized by CD8 T cells.
About The Cover
ONLINE COVER Imaging Airway Smooth Muscle. A new birefringence microscopy technique enables visualization and measurement of the smooth muscle cells lining the human bronchus (red). Called orientation-resolved–optical coherence tomography (OR-OCT), this technique reveals that volunteers with mild allergic asthma have a greatly increased smooth muscle mass compared to healthy individuals (Cho et al. and Adams et al.). [CREDIT: ADAMS ET AL./SCIENCE TRANSLATIONAL MEDICINE]