Research ArticleMalaria

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria

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Science Translational Medicine  28 Sep 2016:
Vol. 8, Issue 358, pp. 358ra128
DOI: 10.1126/scitranslmed.aaf6812

Article Information

vol. 8 no. 358 358ra128

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 13, 2016
  • Accepted for publication September 9, 2016
  • .

Author Information

  1. Sarah J. Higgins1,2,3,
  2. Lisa A. Purcell4,
  3. Karlee L. Silver2,5,
  4. Vanessa Tran2,
  5. Valerie Crowley2,
  6. Michael Hawkes2,6,
  7. Andrea L. Conroy2,
  8. Robert O. Opoka7,
  9. John G. Hay8,
  10. Susan E. Quaggin9,
  11. Gavin Thurston4,
  12. W. Conrad Liles10 and
  13. Kevin C. Kain1,2,*
  1. 1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  2. 2Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, and the Tropical Disease Unit, Department of Medicine, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  3. 3Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  4. 4Regeneron Pharmaceuticals Inc, Tarrytown, NY 10591, USA.
  5. 5Grand Challenges Canada, Toronto, Ontario M5G 1L7, Canada.
  6. 6Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 1C9, Canada.
  7. 7Department of Paediatrics and Child Health, Mulago Hospital and Makerere University, Kampala 7051, Uganda.
  8. 8New York University School of Medicine, New York, NY 10006, USA.
  9. 9Feinberg Cardiovascular Research Institute and Division of Nephrology/Hypertension, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  10. 10Departments of Medicine, Pathology, Pharmacology and Global Health, University of Washington, Seattle, WA 98195, USA.
  1. *Corresponding author. Email: kevin.kain{at}uhn.ca

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