Contents
28 September 2016
Vol 8, Issue 358
Vol 8, Issue 358
Contents
Focus
- What pediatric nonprogressors and natural SIV hosts teach us about HIV
A subset of HIV-infected children shows an unusually benign course of infection that recapitulates key immunological aspects of the natural SIV infection of sooty mangabeys (Muenchhoff et al.).
Research Articles
- Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection
Pediatric HIV patients who do not rapidly develop AIDS are shown to have immunological features similar to nonhuman primates that experience nonpathogenic SIV infection.
- Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation
A bioactive lipokine promotes metabolic resilience of organelles and limits the progression of atherosclerosis.
- Hyperelastic “bone”: A highly versatile, growth factor–free, osteoregenerative, scalable, and surgically friendly biomaterial
A new, mechanically elastic biomaterial can be custom 3D-printed, is surgically friendly, and promotes robust bone regeneration.
- Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria
Angiopoietin-1 is dysregulated in pediatric severe malaria, and targeting it prevents vascular dysfunction and death in a mouse model of cerebral malaria.
Editors' Choice
- Stiff discipline for cells in pulmonary hypertension
Vascular stiffness drives glutaminase expression, promoting anaplerosis necessary for development of pulmonary hypertension.
- A stromal focus reveals tumor immune signatures
A computational analysis of cancer biopsies suggests immunotherapy strategies.
- Navigating the map of human cognition
Coordinated brain gray matter structural changes are associated with behavioral cognitive control.
- Cancer catch and sugar release cue immune attack
Glycocalyx-modifying antibody-enzyme conjugates increase antibody-dependent cell-mediated cytotoxicity against HER2-positive breast cancer cells.
About The Cover
ONLINE COVER A Better Bone Graft. An artificial "bone" material (dark blue and purple area near the top of the image) implanted in mice stimulates and supports regrowth of natural bone (the lower half of the image), complete with blood vessels (round red objects are red blood cells) (H&E stain). This so-called hyperelastic "bone" can be made quickly—3D printed into custom shapes and readily deployed in the operating room. The properties are superior to those of current materials. [CREDIT: JAKUS ET AL./SCIENCE TRANSLATIONAL MEDICINE]