Research ArticleCancer

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells

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Science Translational Medicine  07 Sep 2016:
Vol. 8, Issue 355, pp. 355ra117
DOI: 10.1126/scitranslmed.aag1180

Article Information

vol. 8 no. 355 355ra117

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 11, 2016
  • Accepted for publication August 1, 2016
  • .

Author Information

  1. Bing Z. Carter1,*,
  2. Po Yee Mak1,,
  3. Hong Mu1,,
  4. Hongsheng Zhou1,
  5. Duncan H. Mak1,
  6. Wendy Schober1,
  7. Joel D. Leverson2,
  8. Bin Zhang3,
  9. Ravi Bhatia4,
  10. Xuelin Huang5,
  11. Jorge Cortes6,
  12. Hagop Kantarjian6,
  13. Marina Konopleva1 and
  14. Michael Andreeff1,*
  1. 1Section of Molecular Hematology and Therapy, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  2. 2Department of Oncology Development, AbbVie Inc., North Chicago, IL 60064, USA.
  3. 3Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute, City of Hope Cancer Center, Duarte, CA 91010, USA.
  4. 4Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  5. 5Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  6. 6Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  1. *Corresponding author. Email: bicarter{at}mdanderson.org (B.Z.C.); mandreef{at}mdanderson.org (M.A.)
    • These authors contributed equally to this work.

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