Research ArticleCARDIAC ARRHYTHMIA
Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm
- Rangarajan D. Nadadur1,
- Michael T. Broman2,
- Bastiaan Boukens3,4,
- Stefan R. Mazurek2,
- Xinan Yang1,
- Malou van den Boogaard4,
- Jenna Bekeny1,
- Margaret Gadek1,
- Tarsha Ward5,
- Min Zhang6,7,8,9,10,
- Yun Qiao3,
- James F. Martin6,7,8,9,10,
- Christine E. Seidman5,
- Jon Seidman5,
- Vincent Christoffels4,
- Igor R. Efimov3,
- Elizabeth M. McNally11,
- Christopher R. Weber1 and
- Ivan P. Moskowitz1,*
- 1Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL 60637, USA.
- 2Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
- 3Department of Biomedical Engineering, George Washington University, Washington, DC 20052, USA.
- 4Department of Anatomy, Embryology and Physiology, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.
- 5Department of Genetics, Harvard Medical School, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
- 6Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
- 7Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.
- 8Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston, TX 77030, USA.
- 9Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.
- 10Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA.
- 11Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
- ↵*Corresponding author. Email: imoskowitz{at}uchicago.edu
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Science Translational Medicine 31 Aug 2016:
Vol. 8, Issue 354, pp. 354ra115
DOI: 10.1126/scitranslmed.aaf4891
Vol. 8, Issue 354, pp. 354ra115
DOI: 10.1126/scitranslmed.aaf4891
Rangarajan D. Nadadur
1Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL 60637, USA.
Michael T. Broman
2Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Bastiaan Boukens
3Department of Biomedical Engineering, George Washington University, Washington, DC 20052, USA.
4Department of Anatomy, Embryology and Physiology, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.
Stefan R. Mazurek
2Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Xinan Yang
1Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL 60637, USA.
Malou van den Boogaard
4Department of Anatomy, Embryology and Physiology, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.
Jenna Bekeny
1Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL 60637, USA.
Margaret Gadek
1Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL 60637, USA.
Tarsha Ward
5Department of Genetics, Harvard Medical School, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
Min Zhang
6Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
7Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.
8Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston, TX 77030, USA.
9Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.
10Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA.
Yun Qiao
3Department of Biomedical Engineering, George Washington University, Washington, DC 20052, USA.
James F. Martin
6Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
7Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.
8Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston, TX 77030, USA.
9Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.
10Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA.
Christine E. Seidman
5Department of Genetics, Harvard Medical School, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
Jon Seidman
5Department of Genetics, Harvard Medical School, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
Vincent Christoffels
4Department of Anatomy, Embryology and Physiology, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.
Igor R. Efimov
3Department of Biomedical Engineering, George Washington University, Washington, DC 20052, USA.
Elizabeth M. McNally
11Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Christopher R. Weber
1Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL 60637, USA.
Ivan P. Moskowitz
1Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL 60637, USA.
