Research ArticleCARDIAC ARRHYTHMIA

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm

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Science Translational Medicine  31 Aug 2016:
Vol. 8, Issue 354, pp. 354ra115
DOI: 10.1126/scitranslmed.aaf4891

Article Information

vol. 8 no. 354 354ra115

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 16, 2016
  • Accepted for publication July 31, 2016
  • .

Author Information

  1. Rangarajan D. Nadadur1,
  2. Michael T. Broman2,
  3. Bastiaan Boukens3,4,
  4. Stefan R. Mazurek2,
  5. Xinan Yang1,
  6. Malou van den Boogaard4,
  7. Jenna Bekeny1,
  8. Margaret Gadek1,
  9. Tarsha Ward5,
  10. Min Zhang6,7,8,9,10,
  11. Yun Qiao3,
  12. James F. Martin6,7,8,9,10,
  13. Christine E. Seidman5,
  14. Jon Seidman5,
  15. Vincent Christoffels4,
  16. Igor R. Efimov3,
  17. Elizabeth M. McNally11,
  18. Christopher R. Weber1 and
  19. Ivan P. Moskowitz1,*
  1. 1Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL 60637, USA.
  2. 2Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
  3. 3Department of Biomedical Engineering, George Washington University, Washington, DC 20052, USA.
  4. 4Department of Anatomy, Embryology and Physiology, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.
  5. 5Department of Genetics, Harvard Medical School, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  6. 6Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
  7. 7Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.
  8. 8Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston, TX 77030, USA.
  9. 9Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.
  10. 10Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA.
  11. 11Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  1. *Corresponding author. Email: imoskowitz{at}uchicago.edu

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