31 August 2016
Vol 8, Issue 354

About The Cover

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ONLINE COVER Genomics of Cardiac Rhythm Control. Robust as it is, the human heartbeat can sometimes be irregular. Large genomic studies have pinpointed the genes that can cause these abnormalities, and Nadadur et al. now show in a mouse model of atrial fibrillation that the products of seven of these genes normally act together in a feedback loop that ensures the metronome-like beat of the heart. When the loop goes awry, so does the heartbeat. [CREDIT: A. BARRON AND I. P. MOSKOWITZ, THE UNIVERSITY OF CHICAGO]