Contents
31 August 2016
Vol 8, Issue 354
Vol 8, Issue 354
Contents
Research Articles
- Targeting BCL-2 and ABL/LYN in Philadelphia chromosome–positive acute lymphoblastic leukemia
The combination of venetoclax and dasatinib is synergistically effective in treating Philadelphia chromosome–positive ALL.
- Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm
A mouse model reveals how seven atrial fibrillation–related risk genes form a network to control heartbeat.
Reports
- Origin of the U87MG glioma cell line: Good news and bad news
The DNA profile of the publicly available and widely used glioma cell line U87MG is quite different from that of the original cell line.
Editors' Choice
- Seeing is believing: Tissue clearing makes see-through rodents
A new tissue clearing technique can shrink and make entire animals transparent for full-body microscale imaging.
- Blow the germs away
Lugdunin, a new antibiotic produced by commensal bacteria in the nose, prevents pathogen colonization in humans.
- Food for thought
Insulin signaling in astrocytes regulates glucose uptake into the CNS, altering astrocyte morphology and neural responses to circulating glucose.
- Tasty solution to keeping arteries open
Functionalization conveys inflammation sensitivity to carbohydrate/fat-based nanoparticles yielding targeted drug delivery systems to prevent coronary artery disease progression.
About The Cover
ONLINE COVER Genomics of Cardiac Rhythm Control. Robust as it is, the human heartbeat can sometimes be irregular. Large genomic studies have pinpointed the genes that can cause these abnormalities, and Nadadur et al. now show in a mouse model of atrial fibrillation that the products of seven of these genes normally act together in a feedback loop that ensures the metronome-like beat of the heart. When the loop goes awry, so does the heartbeat. [CREDIT: A. BARRON AND I. P. MOSKOWITZ, THE UNIVERSITY OF CHICAGO]