Research ArticleANTICOAGULATION

Factor XIa–specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis

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Science Translational Medicine  24 Aug 2016:
Vol. 8, Issue 353, pp. 353ra112
DOI: 10.1126/scitranslmed.aaf4331

Article Information

vol. 8 no. 353 353ra112

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 6, 2016
  • Accepted for publication July 11, 2016
  • .

Author Information

  1. Tovo David1,*,
  2. Yun Cheol Kim2,*,
  3. Lauren K. Ely2,*,
  4. Isaac Rondon2,
  5. Huilan Gao3,
  6. Peter O’Brien4,
  7. Michael W. Bolt5,
  8. Anthony J. Coyle3,
  9. Jorge L. Garcia6,
  10. Eric A. Flounders6,
  11. Thomas Mikita2, and
  12. Shaun R. Coughlin1,
  1. 1Cardiovascular Research Institute, University of California, San Francisco, Room SC452P, 555 Mission Bay Boulevard South, San Francisco, CA 94143–3122, USA.
  2. 2Centers for Therapeutic Innovation San Francisco, Pfizer Inc., 1700 Owens Street, San Francisco, CA 94158, USA.
  3. 3Centers for Therapeutic Innovation Boston, Pfizer Inc., 18th Floor, 3 Blackfan Circle, Boston, MA 02115, USA.
  4. 4Pharmacokinetics, Dynamics, and Metabolism Biotherapeutics and Translational Research, Pfizer Inc., 10724 Science Center Drive, San Diego, CA 92121, USA.
  5. 5Drug Safety Research and Development, Pfizer Inc., 1 Burtt Road, Andover, MA 01810, USA.
  6. 6PMI Preclinical, 1031 Bing Street, San Carlos, CA 94070, USA.
  1. Corresponding author. Email: shaun.coughlin{at}ucsf.edu (S.R.C.); thomas.mikita{at}pfizer.com (T.M.)
    • * These authors contributed equally to this work.

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