17 August 2016
Vol 8, Issue 352

About The Cover

Cover image expansion

ONLINE COVER Drug-Induced Regeneration. The Hippo pathway is turned up after development to control organ size, so Fan et al. figured that inhibiting Hippo signaling would instigate tissue growth, to repair any damage. The authors discovered a small molecule that blocks MST1/2 kinase activity—a crucial component of the Hippo signaling cascade. The inhibitor promoted regeneration in four different animal models of liver and intestine tissue injury. Popping a pill to repair an organ may eventually become reality, avoiding more complex biomaterial and cell therapy options. [CREDIT: PROTON-PHOTOS/ISTOCKPHOTO]