Contents
17 August 2016
Vol 8, Issue 352
Vol 8, Issue 352
Contents
Editorial
- Animal-based studies will be essential for precision medicine
Precision medicine will be advanced by systematically integrating animal models of human disease, computational frameworks, and experimental preclinical strategies for validation of clinically actionable findings.
Research Articles
- Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
Manipulation of the Hippo signaling pathway with a reversible and selective small-molecule inhibitor of Hippo kinase MST1/2 provides a therapeutic option for tissue injury and repair.
- ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy
Corticosterone is as effective as cortisol for ACTH suppression but lacks metabolic adverse effects.
- Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy
CD25-targeted near-infrared photoimmunotherapy depletes Tregs and promotes tumor regression.
Editors' Choice
- Airway architect Adam33 in asthma
Soluble Adam33 induces airway remodeling in mice and is necessary for airway hyperresponsiveness.
- Triple threat to colorectal cancer
Combination photo-, gene, and chemotherapies work synergistically to abrogate tumors and prevent recurrence.
About The Cover
ONLINE COVER Drug-Induced Regeneration. The Hippo pathway is turned up after development to control organ size, so Fan et al. figured that inhibiting Hippo signaling would instigate tissue growth, to repair any damage. The authors discovered a small molecule that blocks MST1/2 kinase activity—a crucial component of the Hippo signaling cascade. The inhibitor promoted regeneration in four different animal models of liver and intestine tissue injury. Popping a pill to repair an organ may eventually become reality, avoiding more complex biomaterial and cell therapy options. [CREDIT: PROTON-PHOTOS/ISTOCKPHOTO]