Research ArticleTransplantation

Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy

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Science Translational Medicine  10 Aug 2016:
Vol. 8, Issue 351, pp. 351ra105
DOI: 10.1126/scitranslmed.aae0501

Make way for stem cells

Current conditioning regimens to prepare the host bone marrow for transplantation of donor hematopoietic stem cells (HSCs) can have toxic effects on the patient. As an alternative to chemotherapy or radiation, Chhabra et al. describe a new immunotherapy strategy that clears out host HSCs from the bone marrow in preparation for a transplant. Blockade of the surface antigen CD47 allows phagocytic myeloid cells to engulf host HSCs displaced by antibody targeting, effectively depleting HSCs from the bone marrow of immunocompetent mice. This led to improved engraftment of donor HSCs, with fewer toxic effects for the mice receiving the transplant.

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