10 August 2016
Vol 8, Issue 351

About The Cover

Cover image expansion

ONLINE COVER Immunotherapy Evicts Stem Cells. Patients preparing for hematopoietic stem cell transplantation currently undergo chemotherapy and/or radiation to eradicate their own stem cells from the bone marrow. This allows for the engraftment of transplanted donor stem cells, but also incurs toxic side effects. Chhabra et al.have designed a combination immunotherapy to target a lineage marker on stem cells and activate phagocytic cells to clear them, allowing for elimination of host stem cells from the bone marrow without toxicity. The empty bone marrow niches are evident in this image, which shows mouse bone marrow 7 days after the immunotherapy. [CREDIT: CHHABRA ET AL. /SCIENCE TRANSLATIONAL SCIENCE]