Research ArticleRESPIRATORY DYSFUNCTION

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction

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Science Translational Medicine  03 Aug 2016:
Vol. 8, Issue 350, pp. 350ra103
DOI: 10.1126/scitranslmed.aaf7099

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A little help for the diaphragm

Ventilation-induced diaphragm dysfunction is a common complication of intensive care, where mechanically ventilated patients have to be gradually weaned off ventilator support over an extended period of time until they are finally strong enough to breathe on their own. Salah et al. used a rat model to study the detailed effects of prolonged mechanical ventilation on diaphragm muscles and demonstrate the beneficial effects of a pharmacological intervention with a heat shock protein co-inducer. Through a combination of effects on lipid rafts, mitochondrial efficiency, and other cellular functions, this treatment improved diaphragm muscle force-generating capacity even after multiple days of mechanical ventilation.

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