Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage

Lindsay M. Kindinger; David A. MacIntyre; Yun S. Lee; Julian R. Marchesi; Ann Smith; Julie A. K. McDonald; Vasso Terzidou; Joanna R. Cook; Christoph Lees; Fidan Israfil-Bayli; Yazmin Faiza; Philip Toozs-Hobson; Mark Slack; Stefano Cacciatore; Elaine Holmes; Jeremy K. Nicholson; T. G. Teoh; Phillip R. Bennett

doi:10.1126/scitranslmed.aag1026

Research ArticlePregnancy

Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage

Lindsay M. Kindinger¹,²,³,
David A. MacIntyre¹,*,
Yun S. Lee¹,
Julian R. Marchesi⁴,⁵,
Ann Smith⁵,
Julie A. K. McDonald⁴,
Vasso Terzidou¹,⁶,
Joanna R. Cook¹,
Christoph Lees¹,²,⁷,
Fidan Israfil-Bayli⁸,
Yazmin Faiza⁹,
Philip Toozs-Hobson⁸,
Mark Slack⁹,
Stefano Cacciatore¹,
Elaine Holmes⁴,¹⁰,
Jeremy K. Nicholson⁴,¹⁰,
T. G. Teoh³ and
Phillip R. Bennett¹,²,*

¹Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK.
²Queen Charlotte’s Hospital, Imperial College Healthcare National Health Service (NHS) Trust, London W12 0HS, UK.
³St. Mary’s Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.
⁴Centre for Digestive and Gut Health, Imperial College London, London W2 1NY, UK.
⁵School of Biosciences, Cardiff University, Cardiff CF103AX, UK.
⁶Chelsea and Westminster Hospital, Imperial College Healthcare NHS Trust, London SW10 9NH, UK.
⁷Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven 3000, Belgium.
⁸Birmingham Women’s Hospital NHS Foundation Trust, Edgbaston, Birmingham B15 2TG, UK.
⁹Urogynaecology Department, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
¹⁰Division of Computational Systems Medicine, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.

↵*Corresponding author. Email: d.macintyre{at}imperial.ac.uk (D.A.M.); p.bennett{at}imperial.ac.uk (P.R.B.)

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Science Translational Medicine 03 Aug 2016:
Vol. 8, Issue 350, pp. 350ra102
DOI: 10.1126/scitranslmed.aag1026

Lindsay M. Kindinger

1Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK.

2Queen Charlotte’s Hospital, Imperial College Healthcare National Health Service (NHS) Trust, London W12 0HS, UK.

3St. Mary’s Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.

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David A. MacIntyre

1Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK.

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For correspondence: d.macintyre@imperial.ac.uk p.bennett@imperial.ac.uk

Yun S. Lee

1Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK.

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Julian R. Marchesi

4Centre for Digestive and Gut Health, Imperial College London, London W2 1NY, UK.

5School of Biosciences, Cardiff University, Cardiff CF103AX, UK.

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Ann Smith

5School of Biosciences, Cardiff University, Cardiff CF103AX, UK.

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Julie A. K. McDonald

4Centre for Digestive and Gut Health, Imperial College London, London W2 1NY, UK.

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Vasso Terzidou

1Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK.

6Chelsea and Westminster Hospital, Imperial College Healthcare NHS Trust, London SW10 9NH, UK.

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Joanna R. Cook

1Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK.

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Christoph Lees

1Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK.

2Queen Charlotte’s Hospital, Imperial College Healthcare National Health Service (NHS) Trust, London W12 0HS, UK.

7Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven 3000, Belgium.

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Fidan Israfil-Bayli

8Birmingham Women’s Hospital NHS Foundation Trust, Edgbaston, Birmingham B15 2TG, UK.

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Yazmin Faiza

9Urogynaecology Department, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.

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Philip Toozs-Hobson

8Birmingham Women’s Hospital NHS Foundation Trust, Edgbaston, Birmingham B15 2TG, UK.

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Mark Slack

9Urogynaecology Department, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.

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Stefano Cacciatore

1Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK.

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Elaine Holmes

4Centre for Digestive and Gut Health, Imperial College London, London W2 1NY, UK.

10Division of Computational Systems Medicine, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.

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Jeremy K. Nicholson

4Centre for Digestive and Gut Health, Imperial College London, London W2 1NY, UK.

10Division of Computational Systems Medicine, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.

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T. G. Teoh

3St. Mary’s Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.

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Phillip R. Bennett

1Imperial College Parturition Research Group, Division of the Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, UK.

2Queen Charlotte’s Hospital, Imperial College Healthcare National Health Service (NHS) Trust, London W12 0HS, UK.

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For correspondence: d.macintyre@imperial.ac.uk p.bennett@imperial.ac.uk

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