Research ArticlePregnancy

Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage

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Science Translational Medicine  03 Aug 2016:
Vol. 8, Issue 350, pp. 350ra102
DOI: 10.1126/scitranslmed.aag1026

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A (monofilament) stitch in time

Cervical cerclage, a procedure that uses suture to reinforce the cervical opening, is frequently used to reduce the risk of preterm delivery in women with a history of previous preterm birth or short cervical length. Either monofilament or braided suture can be used for cerclage, but braided is more commonly selected because of its mechanical strength and easier application. A large clinical study by Kindinger et al. now shows that braided cerclage increases the risk of preterm birth and intrauterine death compared to monofilament suture. The authors also found that the braided suture is more conducive to bacterial colonization and increases the risk of vaginal dysbiosis and inflammation, helping to explain the clinical findings.

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