Contents
03 August 2016
Vol 8, Issue 350
Vol 8, Issue 350
Contents
Focus
- Moving the needle: Optimizing classification for glioma
Genomic markers provide unbiased information that is increasingly being used to enhance traditional histopathology approaches for classification of cancer samples.
Research Articles
- Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage
Cervical cerclage using braided suture material disrupts vaginal microbial stability and increases inflammation.
- The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction
BGP-15 reduces ventilation-induced diaphragm dysfunction by improving diaphragm fiber and myosin function and enhancing mitochondrial activity.
- Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression
In lung cancers with low expression of C/EBPα, BMI1 expression correlates with worse prognosis but can be targeted with a drug.
Editors' Choice
- A shocking way to suppress inflammation
Vagus nerve stimulation suppresses inflammation and improves disease activity in rheumatoid arthritis.
- Biomarker changes in early Alzheimer’s disease
Biomarker profiles in early preclinical Alzheimer’s disease may predict progression to Aβ deposition.
- The trash piles up in vascular disease
Dying cells in the vessel wall block their own removal and drive atherosclerosis progression in mice.
- Keep it moving
Colonic transit time correlates with microbial composition and metabolism in the gut.
Letters
- Comment on “Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice”
A report that low doses of resveratrol can suppress intestinal adenoma in a mouse model appears confounded because in a slightly different protocol, resveratrol has the opposite effect.
- Response to comment on “Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice”
Low-dose resveratrol did not have opposite effects on tumorigenesis in standard and high-fat diets.
About The Cover
ONLINE COVER Brain Tumor Trees. This artist's depiction of a brain giving rise to two trees, one healthy and one dying, illustrates the concept of brain tumor genomics, or the idea that tumors arising from the same brain tissue can have vastly different prognoses, depending on their genetic makeup. A Focus article by Roel Verhaak, the winner of this year's AAAS Martin and Rose Wachtel Cancer Research Award, discusses his pioneering research in this field. The winner will also present a lecture based on his research on Friday, 5 August 2016, at the National Institutes of Health. [CREDIT: JAE-JUNE LEE]