Research ArticleHIV

Maternal HIV infection influences the microbiome of HIV-uninfected infants

See allHide authors and affiliations

Science Translational Medicine  27 Jul 2016:
Vol. 8, Issue 349, pp. 349ra100
DOI: 10.1126/scitranslmed.aaf5103

Influencing the infant microbiome

Annually, there are more than 1 million children born to HIV-infected women. Most of these children do not acquire HIV infection, but they experience twice the mortality of children born to HIV-negative women. Bender et al. now report that maternal HIV infection was associated with changes in the microbiome of these HIV-exposed, uninfected infants. Furthermore, they observed that human breast milk oligosaccharides were associated with specific bacterial species in the infant microbiome. The disruption of the HIV-exposed infant’s microbiome may contribute to the increased morbidity and mortality of these infants.