Contents
27 July 2016
Vol 8, Issue 349
Vol 8, Issue 349
Contents
Perspective
- Disciplined approach to drug discovery and early development
Drug R&D requires a disciplined approach anchored in causal human biology through proof-of-concept clinical trials.
Research Articles
- Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1
Transplantation of gene-corrected autologous hepatocytes can cure metabolic disease in a preclinical pig model of hereditary tyrosinemia type 1.
- Maternal HIV infection influences the microbiome of HIV-uninfected infants
Maternal HIV infection may affect the infant’s microbiome, and this may contribute to the increased morbidity and mortality of HIV-exposed, uninfected infants.
- Noninvasive low-level laser therapy for thrombocytopenia
Low-level laser promotes platelet production from megakaryocytes by mitochondrial protection and biogenesis.
Editors' Choice
- AC/DC: Portable diagnostics face the music
Smartphone audio output controls fluid flow in microfluidic networks.
- A sneak peek at personalized medicine in autism?
Early brain enlargement in children with autism may be caused by dysregulation of a specific transcriptional cascade, which may be targeted for pharmacologic interventions.
- Viral infection crosses up antigen presentation to drive autoimmunity
Infection of B cells can change their antigen processing machinery to enable them to promote aggressive autoimmune disease.
- A captive peptide for T cell activation
A protein cage nanoparticle carrying an antigenic peptide induces cytotoxic T cells to destroy melanoma tumors.
Letters
- Comment on “NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis”
Experimental cancer models must consider the role of the immune system.
- Response to comment on “NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis”
Multiple factors may affect the outcome of diabetic patients with cancer treated with antioxidant antidiabetic agents.
About The Cover
ONLINE COVER Let There Be Light. Thrombocytopenia, a condition characterized by a low number of platelets, can manifest from several different insults or from genetics, resulting in uncontrollable bleeding. Rather than platelet transfusion, laser light aimed at the body could stimulate platelet regeneration in vivo. Zhang et al. exposed mice to low-level laser light and found that it induced the generation of blood-producing cells, called megakaryocytes (on cover), in three different mouse models of thrombocytopenia, offering a drug-free, noninvasive therapy for this disease. [CREDIT: ZHANG ET AL./SCIENCE TRANSLATIONAL MEDICINE]