Imaging synaptic density in the living human brain

Sjoerd J. Finnema; Nabeel B. Nabulsi; Tore Eid; Kamil Detyniecki; Shu-fei Lin; Ming-Kai Chen; Roni Dhaher; David Matuskey; Evan Baum; Daniel Holden; Dennis D. Spencer; Joël Mercier; Jonas Hannestad; Yiyun Huang; Richard E. Carson

doi:10.1126/scitranslmed.aaf6667

Research ArticleNeurology

Imaging synaptic density in the living human brain

Sjoerd J. Finnema¹,*,
Nabeel B. Nabulsi¹,
Tore Eid²,
Kamil Detyniecki³,
Shu-fei Lin¹,
Ming-Kai Chen¹,
Roni Dhaher²,
David Matuskey¹,
Evan Baum¹,
Daniel Holden¹,
Dennis D. Spencer⁴,
Joël Mercier⁵,
Jonas Hannestad⁵,†,
Yiyun Huang¹ and
Richard E. Carson¹,⁶

¹Yale Positron Emission Tomography Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA.
²Department of Laboratory Medicine, Yale University, New Haven, CT 06520, USA.
³Department of Neurology, Yale University, New Haven, CT 06520, USA.
⁴Department of Neurosurgery, Yale University, New Haven, CT 06520, USA.
⁵UCB Pharma, B-1420 Braine-l’Alleud, Belgium.
⁶Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.

↵*Corresponding author. Email: sjoerd.finnema{at}yale.edu

↵† Present address: Denali Therapeutics, South San Francisco, CA 94080, USA.

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Science Translational Medicine 20 Jul 2016:
Vol. 8, Issue 348, pp. 348ra96
DOI: 10.1126/scitranslmed.aaf6667

Sjoerd J. Finnema

1Yale Positron Emission Tomography Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA.

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For correspondence: sjoerd.finnema@yale.edu

Nabeel B. Nabulsi

1Yale Positron Emission Tomography Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA.

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Tore Eid

2Department of Laboratory Medicine, Yale University, New Haven, CT 06520, USA.

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Kamil Detyniecki

3Department of Neurology, Yale University, New Haven, CT 06520, USA.

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Shu-fei Lin

1Yale Positron Emission Tomography Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA.

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Ming-Kai Chen

1Yale Positron Emission Tomography Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA.

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Roni Dhaher

2Department of Laboratory Medicine, Yale University, New Haven, CT 06520, USA.

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David Matuskey

1Yale Positron Emission Tomography Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA.

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Evan Baum

1Yale Positron Emission Tomography Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA.

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Daniel Holden

1Yale Positron Emission Tomography Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA.

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Dennis D. Spencer

4Department of Neurosurgery, Yale University, New Haven, CT 06520, USA.

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Joël Mercier

5UCB Pharma, B-1420 Braine-l’Alleud, Belgium.

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Jonas Hannestad

5UCB Pharma, B-1420 Braine-l’Alleud, Belgium.

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Yiyun Huang

1Yale Positron Emission Tomography Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA.

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Richard E. Carson

1Yale Positron Emission Tomography Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA.

6Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.

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Imaging synaptic density in the living human brain

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