Contents

Contents

• Focus

  • A nudge toward participation: Improving clinical trial enrollment with behavioral economics

    By Eric M. VanEpps, Kevin G. Volpp, Scott D. Halpern

    Science Translational Medicine20 Jul 2016 : 348fs13 Full AccessRestricted Access

    Interventions informed by behavioral economics can address barriers to patient enrollment in clinical trials and improve recruitment efforts.

    • Abstract
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• Research Articles

  • Imaging synaptic density in the living human brain

    By Sjoerd J. Finnema, Nabeel B. Nabulsi, Tore Eid, Kamil Detyniecki, Shu-fei Lin, Ming-Kai Chen, Roni Dhaher, David Matuskey, Evan Baum, Daniel Holden, Dennis D. Spencer, Joël Mercier, Jonas Hannestad, Yiyun Huang, Richard E. Carson

    Science Translational Medicine20 Jul 2016 : 348ra96 Full AccessRestricted Access

    Synaptic density in the living human brain was measured with positron emission tomography and a synaptic vesicle glycoprotein 2A tracer.

    • Editor's Summary
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    • Supplementary Materials

  • Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin

    By Yanqing Liu, Xiaoli Zheng, Qinqin Yu, Hua Wang, Fuqing Tan, Qianying Zhu, Lingmin Yuan, Huidi Jiang, Lushan Yu, Su Zeng

    Science Translational Medicine20 Jul 2016 : 348ra97 Full AccessRestricted Access

    The expression of drug transporter OCT2 is suppressed in renal cell carcinoma, and targeting this pathway sensitizes the tumor to oxaliplatin.

    • Editor's Summary
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    • Supplementary Materials

  • Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

    By Catherine E. Winbanks, Kate T. Murphy, Bianca C. Bernardo, Hongwei Qian, Yingying Liu, Patricio V. Sepulveda, Claudia Beyer, Adam Hagg, Rachel E. Thomson, Justin L. Chen, Kelly L. Walton, Kate L. Loveland, Julie R. McMullen, Buel D. Rodgers, Craig A. Harrison, Gordon S. Lynch, Paul Gregorevic

    Science Translational Medicine20 Jul 2016 : 348ra98 Full AccessRestricted Access

    Muscle-directed Smad7 gene delivery prevents the loss of skeletal muscle mass and strength in mouse models of cachexia, an important contributor to poor prognosis in patients with advanced cancer.

    • Editor's Summary
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    • Supplementary Materials

• Editors' Choice

  • Theranostic nanoparticles give the best of both worlds

    By Conor Evans

    Science Translational Medicine20 Jul 2016 : 348ec114 Full AccessRestricted Access

    A fluorescent nanoparticle delivering gene-silencing therapies shows promise for the treatment of anaplastic thyroid cancer.

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  • Mapping a path for precision cancer therapies

    By Kris C. Wood

    Science Translational Medicine20 Jul 2016 : 348ec115 Full AccessRestricted Access

    A large-scale pharmacogenomic analysis of human cancer cell lines identifies cancer lineage- and genotype-selective therapies.

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  • Nature vs. nurture in adipocyte responses to high-fat feeding

    By Sarah A. Stanley

    Science Translational Medicine20 Jul 2016 : 348ec116 Full AccessRestricted Access

    Adipose cell proliferation in response to high-fat feeding is regulated by estrogen and the adipocyte microenvironment.

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  • Insulin delivery never tasted so good

    By Bret D. Ulery

    Science Translational Medicine20 Jul 2016 : 348ec117 Full AccessRestricted Access

    Dual-functionalized nanocarriers survive digestion and trafficking to the bloodstream, suggesting that one dose per day controlled oral insulin delivery may be possible in the future.

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