20 July 2016
Vol 8, Issue 348

About The Cover

Cover image expansion

ONLINE COVER Seeing Synapses. Many neurological and psychiatric diseases are characterized by misfiring synapses, but there is no way to visualize aberrant neuronal connections in the living brain. Finnema and colleagues developed a noninvasive PET imaging approach to "see" human synapses by using an agent that targets the synaptic vesicle glycoprotein 2A. Such imaging allowed the authors to visualize synaptic density differences in healthy (on cover) and epileptic human brains in living patients. [CREDIT: FINNEMA ET AL./SCIENCE TRANSLATIONAL MEDICINE]