06 July 2016
Vol 8, Issue 346

About The Cover

Cover image expansion

ONLINE COVER A Permanent Home. It has long been debated whether human cartilage renews itself with age, disease, or damage. By carbon-dating knee joint tissues from moderately loaded areas (a stained sample from the lateral condyle is shown on cover) as well as highly loaded areas of both healthy and osteoarthritic human subjects, Heinemeier et al. provide evidence that cartilage, in fact, remains permanent over our lifetime. Such permanence can affect the design of new therapeutics and tissue engineering strategies to repair damaged joints. [CREDIT: HEINEMEIER ET AL./SCIENCE TRANSLATIONAL MEDICINE]