Contents
06 July 2016
Vol 8, Issue 346
Vol 8, Issue 346
Contents
Focus
- Small cell lung cancer: Time to revisit DNA-damaging chemotherapy
Rational use of DNA-damaging chemotherapy, with new combinations to heighten DNA replication stress, could improve outcomes in small cell lung cancer.
Research Articles
- Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage
The turnover of cartilage collagen matrix is minimal in human adults and is not influenced by disease.
- Robust classification of bacterial and viral infections via integrated host gene expression diagnostics
An 18-gene panel distinguishes patients with bacterial and viral infections as well as those with inflammation not caused by infection.
- Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer
Detection of circulating tumor DNA in patients with resected stage II colon cancer provides evidence of residual disease.
Editors' Choice
- The gut takes a “Toll” on the lung
A Toll-like receptor ligand secreted by injured intestine causes acute lung injury in necrotizing enterocolitis.
- Lym(fat)ics
Increased body weight negatively affects lymphatic function independent of diet.
- The future is unsupervised
A new algorithm infers shared biology behind detected gene expression levels.
- Has the tooth fairy entered the realm of science?
Analysis of baby teeth links prenatal and infant exposure to metals with development of schizophrenia.
About The Cover
ONLINE COVER A Permanent Home. It has long been debated whether human cartilage renews itself with age, disease, or damage. By carbon-dating knee joint tissues from moderately loaded areas (a stained sample from the lateral condyle is shown on cover) as well as highly loaded areas of both healthy and osteoarthritic human subjects, Heinemeier et al. provide evidence that cartilage, in fact, remains permanent over our lifetime. Such permanence can affect the design of new therapeutics and tissue engineering strategies to repair damaged joints. [CREDIT: HEINEMEIER ET AL./SCIENCE TRANSLATIONAL MEDICINE]