Contents

Contents

• Focus

  • Small cell lung cancer: Time to revisit DNA-damaging chemotherapy

    By Anish Thomas, Yves Pommier

    Science Translational Medicine06 Jul 2016 : 346fs12 Full AccessRestricted Access

    Rational use of DNA-damaging chemotherapy, with new combinations to heighten DNA replication stress, could improve outcomes in small cell lung cancer.

    • Abstract
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• Research Articles

  • Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage

    By Katja M. Heinemeier, Peter Schjerling, Jan Heinemeier, Mathias B. Møller, Michael R. Krogsgaard, Tomas Grum-Schwensen, Michael M. Petersen, Michael Kjaer

    Science Translational Medicine06 Jul 2016 : 346ra90 Full AccessRestricted Access

    The turnover of cartilage collagen matrix is minimal in human adults and is not influenced by disease.

    • Editor's Summary
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  • Robust classification of bacterial and viral infections via integrated host gene expression diagnostics

    By Timothy E. Sweeney, Hector R. Wong, Purvesh Khatri

    Science Translational Medicine06 Jul 2016 : 346ra91 Full AccessRestricted Access

    An 18-gene panel distinguishes patients with bacterial and viral infections as well as those with inflammation not caused by infection.

    • Editor's Summary
    • Abstract
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  • Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

    By Jeanne Tie, Yuxuan Wang, Cristian Tomasetti, Lu Li, Simeon Springer, Isaac Kinde, Natalie Silliman, Mark Tacey, Hui-Li Wong, Michael Christie, Suzanne Kosmider, Iain Skinner, Rachel Wong, Malcolm Steel, Ben Tran, Jayesh Desai, Ian Jones, Andrew Haydon, Theresa Hayes, Tim J. Price, Robert L. Strausberg, Luis A. Diaz, Jr., Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Peter Gibbs

    Science Translational Medicine06 Jul 2016 : 346ra92 Full AccessRestricted Access

    Detection of circulating tumor DNA in patients with resected stage II colon cancer provides evidence of residual disease.

    • Editor's Summary
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• Editors' Choice

  • The gut takes a “Toll” on the lung

    By Mallar Bhattacharya

    Science Translational Medicine06 Jul 2016 : 346ec106 Full AccessRestricted Access

    A Toll-like receptor ligand secreted by injured intestine causes acute lung injury in necrotizing enterocolitis.

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  • Lym(fat)ics

    By Susan Napier Thomas

    Science Translational Medicine06 Jul 2016 : 346ec107 Full AccessRestricted Access

    Increased body weight negatively affects lymphatic function independent of diet.

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  • The future is unsupervised

    By Casey S. Greene

    Science Translational Medicine06 Jul 2016 : 346ec108 Full AccessRestricted Access

    A new algorithm infers shared biology behind detected gene expression levels.

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  • Has the tooth fairy entered the realm of science?

    By Olga Peñagarikano

    Science Translational Medicine06 Jul 2016 : 346ec109 Full AccessRestricted Access

    Analysis of baby teeth links prenatal and infant exposure to metals with development of schizophrenia.

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