Contents
29 June 2016
Vol 8, Issue 345
Vol 8, Issue 345
Contents
Focus
- Zooming in on selectins in cancer
Selectins are involved in leukocyte and cancer cell trafficking, which can be targeted with drugs and nanoparticles (Shamay et al., this issue).
Perspective
- Multicriteria decision analysis and core values for enhancing vaccine-related decision-making
Prioritization of vaccine development requires multicriteria decision-making based on disease severity, vaccine safety, and economic benefits.
Research Articles
- P-selectin is a nanotherapeutic delivery target in the tumor microenvironment
P-selectin–targeted nanoparticles deliver chemotherapy to tumors, particularly when combined with radiation.
- Low α-defensin gene copy number increases the risk for IgA nephropathy and renal dysfunction
Low copy number of the α-defensin DEFA1A3 locus increases the risk for IgA nephropathy.
- Tumor-derived circulating endothelial cell clusters in colorectal cancer
A population of cell clusters circulating in cancer patients consist of tumor-derived endothelial cells reflecting features of the tumor vasculature.
Editors' Choice
- You are what your great grandmother ate
Maternal dietary habits impact mitochondrial function in the next generation.
- Losing inhibitions: Expect the unexpected
Careful examination of the role of programmed death ligand-1 (PD-L1) on T cells reveals surprising results.
- AML survives with a little help from its friends
An energy boost from neighbors protects leukemia stem cells from lethal chemotherapy.
- An old drug auditions for a new leading role
An FDA-approved drug for multiple sclerosis, dimethyl fumarate, prevents the death of dopaminergic neurons in a mouse model of Parkinson’s disease.
About The Cover
ONLINE COVER Selectin(g) a Treatment Target. P-selectin is a leukocyte adhesion molecule that is usually present on activated blood vessels. P-selectin is often found on tumor vasculature as well, and its expression can be induced by radiation. Shamay et al. designed fucoidan nanoparticles to take advantage of these observations. The nanoparticles, which contain chemotherapy drugs, bind to blood vessels expressing P-selectin and thus deliver drugs directly to tumors. This image depicts a melanoma lung metastasis, with all cell nuclei in blue, all blood vessels in green, and P-selectin shown in red. Blood vessels positive for P-selectin are yellow, highlighting their predominance in the tumor. [CREDIT: SHAMAY ET AL./SCIENCE TRANSLATIONAL MEDICINE]