22 June 2016
Vol 8, Issue 344

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ONLINE COVER Neurons on the Run. Anesthesia exposure in early life can have detrimental effects on subsequent learning in children. To address this issue, Huang et al. examined mouse models of neonatal anesthesia exposure and identified a treatment that can be given together with anesthesia to prevent learning deficits, as demonstrated by the animals' performance of learned motor tasks. This image shows active neurons in the primary motor cortex of a mouse running on a treadmill. Active neurons contain increased amounts of calcium, which can be detected by a genetically encoded calcium sensor. Images were taken at three different time points, which are represented by green, red, and blue. [CREDIT: J. CICHON/NEW YORK UNIVERSITY SCHOOL OF MEDICINE]