Contents
22 June 2016
Vol 8, Issue 344
Vol 8, Issue 344
Contents
Editorial
- Enhancing quality of life as a goal for anticancer therapeutics
Translational cancer research requires a quality-of-life–driven agenda.
Research Articles
- Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
Rectal organoids from subjects with cystic fibrosis can be used to assess responses to drugs that modulate CFTR.
- Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits
Administration of an AMPAkine prevents long-term deficits induced by repeated neonatal anesthesia.
- Electromechanical cardioplasty using a wrapped elasto-conductive epicardial mesh
A mesh made of a conductive nanowire composite can be wrapped around the heart to improve hemodynamics in experimental heart failure in rodents.
Editors' Choice
- Fire extinguishers turn down the gain on pain
Disruption of NLRP3 inflammasome-mediated IL-1β production in microglia diminishes opioid-induced hyperalgesia in chronic neuropathic pain.
- The brainstem and traumatic brain injury
Traumatic brain injury damages arousal-producing neurons in the brainstem and hypothalamus.
- The splice of life: Understanding human macrophage polarization
Alternative splicing is highly active in human inflammatory macrophages and may be a causal factor in the genetic risk of developing cardiometabolic disease.
- Targeting the cancer cells that just won’t go away
A selective inhibitor of KDM5 family lysine demethylases targets drug-tolerant persister cells.
About The Cover
ONLINE COVER Neurons on the Run. Anesthesia exposure in early life can have detrimental effects on subsequent learning in children. To address this issue, Huang et al. examined mouse models of neonatal anesthesia exposure and identified a treatment that can be given together with anesthesia to prevent learning deficits, as demonstrated by the animals' performance of learned motor tasks. This image shows active neurons in the primary motor cortex of a mouse running on a treadmill. Active neurons contain increased amounts of calcium, which can be detected by a genetically encoded calcium sensor. Images were taken at three different time points, which are represented by green, red, and blue. [CREDIT: J. CICHON/NEW YORK UNIVERSITY SCHOOL OF MEDICINE]