Antibiotics, birth mode, and diet shape microbiome maturation during early life

Nicholas A. Bokulich; Jennifer Chung; Thomas Battaglia; Nora Henderson; Melanie Jay; Huilin Li; Arnon D. Lieber; Fen Wu; Guillermo I. Perez-Perez; Yu Chen; William Schweizer; Xuhui Zheng; Monica Contreras; Maria Gloria Dominguez-Bello; Martin J. Blaser

doi:10.1126/scitranslmed.aad7121

Research ArticleMicrobiome

Antibiotics, birth mode, and diet shape microbiome maturation during early life

Nicholas A. Bokulich¹,
Jennifer Chung¹,
Thomas Battaglia¹,
Nora Henderson¹,
Melanie Jay¹,²,
Huilin Li³,
Arnon D. Lieber¹,
Fen Wu¹,²,
Guillermo I. Perez-Perez¹,⁴,
Yu Chen¹,²,
William Schweizer⁵,
Xuhui Zheng⁴,
Monica Contreras¹,
Maria Gloria Dominguez-Bello¹ and
Martin J. Blaser¹,⁴,⁶,*

¹Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.
²Department of Population Health, New York University Langone Medical Center, New York, NY 10016, USA.
³Division of Biostatistics, Department of Population Health and Department of Environmental Medicine, New York University Langone Medical Center, New York, NY 10016, USA.
⁴Department of Microbiology, New York University Langone Medical Center, New York, NY 10016, USA.
⁵Department of Obstetrics and Gynecology, New York University Langone Medical Center, New York, NY 10016, USA.
⁶New York Harbor Department of Veterans Affairs Medical Center, New York, NY 10010, USA.

↵*Corresponding author. Email: martin.blaser{at}nyumc.org

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Science Translational Medicine 15 Jun 2016:
Vol. 8, Issue 343, pp. 343ra82
DOI: 10.1126/scitranslmed.aad7121

Nicholas A. Bokulich

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

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Jennifer Chung

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

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Thomas Battaglia

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

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Nora Henderson

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

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Melanie Jay

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

2Department of Population Health, New York University Langone Medical Center, New York, NY 10016, USA.

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Huilin Li

3Division of Biostatistics, Department of Population Health and Department of Environmental Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

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Arnon D. Lieber

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

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Fen Wu

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

2Department of Population Health, New York University Langone Medical Center, New York, NY 10016, USA.

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Guillermo I. Perez-Perez

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

4Department of Microbiology, New York University Langone Medical Center, New York, NY 10016, USA.

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Yu Chen

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

2Department of Population Health, New York University Langone Medical Center, New York, NY 10016, USA.

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William Schweizer

5Department of Obstetrics and Gynecology, New York University Langone Medical Center, New York, NY 10016, USA.

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Xuhui Zheng

4Department of Microbiology, New York University Langone Medical Center, New York, NY 10016, USA.

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Monica Contreras

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

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Maria Gloria Dominguez-Bello

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

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Martin J. Blaser

1Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA.

4Department of Microbiology, New York University Langone Medical Center, New York, NY 10016, USA.

6New York Harbor Department of Veterans Affairs Medical Center, New York, NY 10010, USA.

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For correspondence: martin.blaser@nyumc.org

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A longitudinal study of intestinal microbiota in children and their mothers shows that antibiotics, cesarean section, and infant formula alter patterns of microbial acquisition and succession during the first 2 years of childhood.

Antibiotics, birth mode, and diet shape microbiome maturation during early life

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