08 June 2016
Vol 8, Issue 342

About The Cover

Cover image expansion

ONLINE COVER Silencing the Inflammatory Storm. The current standard of care after a heart attack doesn't directly address vascular inflammation—a process mediated by adhesion molecules lining the blood vessels that can recruit immune cells and increase risk of plaque rupture. Sager and colleagues therefore designed a nanomedicine approach that simultaneously silenced multiple adhesion molecules in the arteries. Nanoparticle with five small interfering RNAs (siRNAs), as illustrated on cover, were given to mice after myocardial infarction, leading to reduced numbers of leukocytes recruited to the aortae as well as reduced plaque inflammation. Such multipronged silencing of adhesion molecules could complement existing therapies in humans. [CREDIT: E. MARUSHCHENKO/ELLA MARU STUDIO]