Research ArticleCancer

Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma

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Science Translational Medicine  01 Jun 2016:
Vol. 8, Issue 341, pp. 341ra75
DOI: 10.1126/scitranslmed.aad9784

Article Information

vol. 8 no. 341 341ra75

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 4, 2015
  • Accepted for publication May 2, 2016
  • .

Author Information

  1. Timothy F. Cloughesy1,
  2. Joseph Landolfi2,
  3. Daniel J. Hogan3,
  4. Stephen Bloomfield2,
  5. Bob Carter4,
  6. Clark C. Chen4,
  7. J. Bradley Elder5,
  8. Steven N. Kalkanis6,
  9. Santosh Kesari4,*,
  10. Albert Lai1,
  11. Ian Y. Lee6,
  12. Linda M. Liau1,
  13. Tom Mikkelsen6,,
  14. Phioanh Leia Nghiemphu1,
  15. David Piccioni4,
  16. Tobias Walbert6,
  17. Alice Chu3,
  18. Asha Das3,
  19. Oscar R. Diago3,
  20. Dawn Gammon3,
  21. Harry E. Gruber3,
  22. Michelle Hanna7,8,
  23. Douglas J. Jolly3,
  24. Noriyuki Kasahara9,
  25. David McCarthy7,
  26. Leah Mitchell3,
  27. Derek Ostertag3,
  28. Joan M. Robbins3,
  29. Maria Rodriguez-Aguirre3 and
  30. Michael A. Vogelbaum10,
  1. 1Department of Neuro-Oncology and Department of Neurosurgery, 710 Westwood Plaza, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  2. 2New Jersey Neuroscience Institute, John F. Kennedy Medical Center, 65 James Street, Edison, NJ 08820, USA.
  3. 3Tocagen Inc., 3030 Bunker Hill Street, San Diego, CA 92109, USA.
  4. 4Moores Cancer Center, Department of Neurosciences, University of California, San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA.
  5. 5Ohio State University Wexner Medical Center, 410 West 10th Avenue, Columbus, OH 43210, USA.
  6. 6Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
  7. 7Ribomed Biotechnologies Inc., 3030 Bunker Hill Street, San Diego, CA 92109, USA.
  8. 8University of Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA.
  9. 9Department of Cell Biology and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
  10. 10Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
  1. Corresponding author. Email: vogelbm{at}ccf.org
  • * Present address: John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA.

  • Present address: Ontario Brain Institute, 438 University Avenue, Suite 1618, Toronto, Ontario M5G 2K8, Canada.

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