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Research ArticleCardiovascular Disease
Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase
- Svetlana N. Reilly1,*,†,
- Xing Liu1,*,
- Ricardo Carnicer1,
- Alice Recalde1,
- Anna Muszkiewicz2,
- Raja Jayaram1,
- Maria Cristina Carena1,
- Rohan Wijesurendra1,
- Matilde Stefanini1,
- Nicoletta C. Surdo1,
- Oliver Lomas1,
- Chandana Ratnatunga3,
- Rana Sayeed3,
- George Krasopoulos3,
- Timothy Rajakumar4,
- Alfonso Bueno-Orovio2,
- Sander Verheule5,
- Tudor A. Fulga4,
- Blanca Rodriguez2,
- Ulrich Schotten5 and
- Barbara Casadei1,*,†
- 1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
- 2Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK.
- 3Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.
- 4Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
- 5Department of Physiology, University of Maastricht, 6211 LK Maastricht, Netherlands.
- ↵†Corresponding author. Email: barbara.casadei{at}cardiov.ox.ac.uk (B.C.); svetlana.reilly{at}cardiov.ox.ac.uk (S.N.R.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 25 May 2016:
Vol. 8, Issue 340, pp. 340ra74
DOI: 10.1126/scitranslmed.aac4296
Vol. 8, Issue 340, pp. 340ra74
DOI: 10.1126/scitranslmed.aac4296
Svetlana N. Reilly
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Xing Liu
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Ricardo Carnicer
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Alice Recalde
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Anna Muszkiewicz
2Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK.
Raja Jayaram
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Maria Cristina Carena
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Rohan Wijesurendra
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Matilde Stefanini
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Nicoletta C. Surdo
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Oliver Lomas
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Chandana Ratnatunga
3Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Rana Sayeed
3Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.
George Krasopoulos
3Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Timothy Rajakumar
4Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Alfonso Bueno-Orovio
2Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK.
Sander Verheule
Tudor A. Fulga
4Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Blanca Rodriguez
2Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK.
Ulrich Schotten
Barbara Casadei
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
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