Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

Svetlana N. Reilly; Xing Liu; Ricardo Carnicer; Alice Recalde; Anna Muszkiewicz; Raja Jayaram; Maria Cristina Carena; Rohan Wijesurendra; Matilde Stefanini; Nicoletta C. Surdo; Oliver Lomas; Chandana Ratnatunga; Rana Sayeed; George Krasopoulos; Timothy Rajakumar; Alfonso Bueno-Orovio; Sander Verheule; Tudor A. Fulga; Blanca Rodriguez; Ulrich Schotten; Barbara Casadei

doi:10.1126/scitranslmed.aac4296

Research ArticleCardiovascular Disease

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

Svetlana N. Reilly¹,*,†,
Xing Liu¹,*,
Ricardo Carnicer¹,
Alice Recalde¹,
Anna Muszkiewicz²,
Raja Jayaram¹,
Maria Cristina Carena¹,
Rohan Wijesurendra¹,
Matilde Stefanini¹,
Nicoletta C. Surdo¹,
Oliver Lomas¹,
Chandana Ratnatunga³,
Rana Sayeed³,
George Krasopoulos³,
Timothy Rajakumar⁴,
Alfonso Bueno-Orovio²,
Sander Verheule⁵,
Tudor A. Fulga⁴,
Blanca Rodriguez²,
Ulrich Schotten⁵ and
Barbara Casadei¹,*,†

¹Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
²Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK.
³Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.
⁴Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
⁵Department of Physiology, University of Maastricht, 6211 LK Maastricht, Netherlands.

↵†Corresponding author. Email: barbara.casadei{at}cardiov.ox.ac.uk (B.C.); svetlana.reilly{at}cardiov.ox.ac.uk (S.N.R.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 25 May 2016:
Vol. 8, Issue 340, pp. 340ra74
DOI: 10.1126/scitranslmed.aac4296

Svetlana N. Reilly

1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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For correspondence: barbara.casadei@cardiov.ox.ac.uk svetlana.reilly@cardiov.ox.ac.uk

Xing Liu

1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Ricardo Carnicer

1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Alice Recalde

1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Anna Muszkiewicz

2Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK.

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Raja Jayaram

1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Maria Cristina Carena

1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Rohan Wijesurendra

1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Matilde Stefanini

1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Nicoletta C. Surdo

1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Oliver Lomas

1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Chandana Ratnatunga

3Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Rana Sayeed

3Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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George Krasopoulos

3Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Timothy Rajakumar

4Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.

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Alfonso Bueno-Orovio

2Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK.

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Sander Verheule

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Tudor A. Fulga

4Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.

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Blanca Rodriguez

2Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK.

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Ulrich Schotten

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Barbara Casadei

1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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For correspondence: barbara.casadei@cardiov.ox.ac.uk svetlana.reilly@cardiov.ox.ac.uk

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Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

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