Research ArticleCardiovascular Disease
Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase
- Svetlana N. Reilly1,*,†,
- Xing Liu1,*,
- Ricardo Carnicer1,
- Alice Recalde1,
- Anna Muszkiewicz2,
- Raja Jayaram1,
- Maria Cristina Carena1,
- Rohan Wijesurendra1,
- Matilde Stefanini1,
- Nicoletta C. Surdo1,
- Oliver Lomas1,
- Chandana Ratnatunga3,
- Rana Sayeed3,
- George Krasopoulos3,
- Timothy Rajakumar4,
- Alfonso Bueno-Orovio2,
- Sander Verheule5,
- Tudor A. Fulga4,
- Blanca Rodriguez2,
- Ulrich Schotten5 and
- Barbara Casadei1,*,†
- 1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
- 2Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK.
- 3Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.
- 4Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
- 5Department of Physiology, University of Maastricht, 6211 LK Maastricht, Netherlands.
- ↵†Corresponding author. Email: barbara.casadei{at}cardiov.ox.ac.uk (B.C.); svetlana.reilly{at}cardiov.ox.ac.uk (S.N.R.)
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Science Translational Medicine 25 May 2016:
Vol. 8, Issue 340, pp. 340ra74
DOI: 10.1126/scitranslmed.aac4296
