Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

Trevor T. Price; Monika L. Burness; Ayelet Sivan; Matthew J. Warner; Renee Cheng; Clara H. Lee; Lindsey Olivere; Karrie Comatas; John Magnani; H. Kim Lyerly; Qing Cheng; Chad M. McCall; Dorothy A. Sipkins

doi:10.1126/scitranslmed.aad4059

Research ArticleCancer

Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

Trevor T. Price¹,
Monika L. Burness²,
Ayelet Sivan³,
Matthew J. Warner¹,
Renee Cheng¹,
Clara H. Lee¹,
Lindsey Olivere¹,
Karrie Comatas⁴,
John Magnani⁵,
H. Kim Lyerly⁴,
Qing Cheng⁴,
Chad M. McCall⁶ and
Dorothy A. Sipkins¹,*

¹Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, NC 27707, USA.
²Division of Hematology/Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
³Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA.
⁴Department of Surgery, Duke University, Durham, NC 27707, USA.
⁵GlycoMimetics Inc., Rockville, MD 20850, USA.
⁶Department of Pathology, Duke University, Durham, NC 27707, USA.

↵*Corresponding author. Email: dorothy.sipkins{at}dm.duke.edu

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Science Translational Medicine 25 May 2016:
Vol. 8, Issue 340, pp. 340ra73
DOI: 10.1126/scitranslmed.aad4059

Trevor T. Price

1Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, NC 27707, USA.

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Monika L. Burness

2Division of Hematology/Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

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Ayelet Sivan

3Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA.

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Matthew J. Warner

1Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, NC 27707, USA.

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Renee Cheng

1Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, NC 27707, USA.

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Clara H. Lee

1Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, NC 27707, USA.

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Lindsey Olivere

1Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, NC 27707, USA.

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Karrie Comatas

4Department of Surgery, Duke University, Durham, NC 27707, USA.

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John Magnani

5GlycoMimetics Inc., Rockville, MD 20850, USA.

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H. Kim Lyerly

4Department of Surgery, Duke University, Durham, NC 27707, USA.

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Qing Cheng

4Department of Surgery, Duke University, Durham, NC 27707, USA.

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Chad M. McCall

6Department of Pathology, Duke University, Durham, NC 27707, USA.

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Dorothy A. Sipkins

1Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, NC 27707, USA.

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For correspondence: dorothy.sipkins@dm.duke.edu

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Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

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