25 May 2016
Vol 8, Issue 340

About The Cover

Cover image expansion

ONLINE COVER Lurking in the Shadows. Breast cancer patients can present with very late metastasis, years after completing treatment, because breast cancer cells can remain in the bone marrow and escape the effects of treatment. Price et al. have characterized specific niches in the bone marrow where these cancer cells can remain dormant, as well as proteins that allow these cells to enter the bone and keep them there. In this image, the blood vessels are red, the tumor cells are cyan, and green shows E-selectin, which regulates the entry of cancer cells into bone. [CREDIT: PRICE ET AL./SCIENCE TRANSLATIONAL MEDICINE]