Contents
25 May 2016
Vol 8, Issue 340
Vol 8, Issue 340
Contents
Editorial
- Treating the enigmatic “exceptional responders” as patients with undiagnosed diseases
“Exceptional responders” teach researchers how to improve therapies and can be assessed in the same way as patients with undiagnosed diseases.
Research Articles
- Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease
β-Amyloid protein oligomerization and fibrillization, known to be pathogenic in Alzheimer’s disease, may play a physiological role in microbial entrapment and innate immunity.
- Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone
Breast cancer cells traffic to and from the peripheral blood within specific vascular niches, and this migration can be therapeutically targeted.
- Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase
Atrial microRNA-31 up-regulation causes dystrophin and nNOS depletion, which in turn contributes to the electrical phenotype of atrial fibrillation.
Editors' Choice
- Unwanted guests: Bacterial microbiome in COPD
The bacterial microbiome promotes IL-17A–driven inflammation in a mouse model of COPD.
- Nothing but a hound dog
A deep learning algorithm sniffs out chromatin accessibility marks.
- Size matters: A growth chart for the brain connectome
A growth chart to track the development of neuronal networks may be able to predict attention deficits in young people.
- Nanoparticle gets the worm
Delivery of antifilarial drug to lymphatic tissues using nanoparticles eliminates filarial worm infections.
About The Cover
ONLINE COVER Lurking in the Shadows. Breast cancer patients can present with very late metastasis, years after completing treatment, because breast cancer cells can remain in the bone marrow and escape the effects of treatment. Price et al. have characterized specific niches in the bone marrow where these cancer cells can remain dormant, as well as proteins that allow these cells to enter the bone and keep them there. In this image, the blood vessels are red, the tumor cells are cyan, and green shows E-selectin, which regulates the entry of cancer cells into bone. [CREDIT: PRICE ET AL./SCIENCE TRANSLATIONAL MEDICINE]