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Research ArticleGraft-Versus-Host Disease
Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice
- Yusuke Shono1,*,
- Melissa D. Docampo1,
- Jonathan U. Peled1,2,3,
- Suelen M. Perobelli1,
- Enrico Velardi1,4,
- Jennifer J. Tsai1,
- Ann E. Slingerland1,
- Odette M. Smith1,
- Lauren F. Young1,
- Jyotsna Gupta1,
- Sophia R. Lieberman1,
- Hillary V. Jay1,
- Katya F. Ahr1,
- Kori A. Porosnicu Rodriguez1,
- Ke Xu1,
- Marco Calarfiore1,
- Hendrik Poeck1,
- Silvia Caballero1,
- Sean M. Devlin5,
- Franck Rapaport6,
- Jarrod A. Dudakov1,7,
- Alan M. Hanash2,3,
- Boglarka Gyurkocza2,3,
- George F. Murphy8,
- Camilla Gomes8,
- Chen Liu9,
- Eli L. Moss10,
- Shannon B. Falconer10,
- Ami S. Bhatt10,
- Ying Taur2,11,
- Eric G. Pamer1,2,11,
- Marcel R. M. van den Brink1,2,3,*,† and
- Robert R. Jenq2,3,*,†
- 1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- 2Weill Medical College of Cornell University, New York, NY 10065, USA.
- 3Adult BMT (Bone Marrow Transplant) Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- 4Department of Clinical and Experimental Medicine, University of Perugia, Perugia 06135, Italy.
- 5Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- 6Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- 7Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
- 8Program in Dermatopathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 9Department of Pathology and Laboratory Medicine, New Jersey Medical School and Robert Wood Johnson Medical School, Rutgers University, Newark, NJ 08903, USA.
- 10Department of Medicine and Genetics, Stanford University, Stanford, CA 94143, USA.
- 11Infectious Disease Service, Lucille Castori Center for Microbes, Inflammation and Cancer, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- ↵*Corresponding author. Email: jenqr{at}mskcc.org (R.R.J.); shonoy{at}mskcc.org (Y.S.); vandenbm{at}mskcc.org (M.R.M.v.d.B)
↵† These authors contributed equally to this work.
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Science Translational Medicine 18 May 2016:
Vol. 8, Issue 339, pp. 339ra71
DOI: 10.1126/scitranslmed.aaf2311
Vol. 8, Issue 339, pp. 339ra71
DOI: 10.1126/scitranslmed.aaf2311
Yusuke Shono
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Melissa D. Docampo
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jonathan U. Peled
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2Weill Medical College of Cornell University, New York, NY 10065, USA.
3Adult BMT (Bone Marrow Transplant) Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Suelen M. Perobelli
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Enrico Velardi
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
4Department of Clinical and Experimental Medicine, University of Perugia, Perugia 06135, Italy.
Jennifer J. Tsai
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Ann E. Slingerland
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Odette M. Smith
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Lauren F. Young
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jyotsna Gupta
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Sophia R. Lieberman
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Hillary V. Jay
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Katya F. Ahr
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Kori A. Porosnicu Rodriguez
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Ke Xu
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Marco Calarfiore
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Hendrik Poeck
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Silvia Caballero
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Sean M. Devlin
5Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Franck Rapaport
6Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jarrod A. Dudakov
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
7Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Alan M. Hanash
2Weill Medical College of Cornell University, New York, NY 10065, USA.
3Adult BMT (Bone Marrow Transplant) Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Boglarka Gyurkocza
2Weill Medical College of Cornell University, New York, NY 10065, USA.
3Adult BMT (Bone Marrow Transplant) Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
George F. Murphy
8Program in Dermatopathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Camilla Gomes
8Program in Dermatopathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Chen Liu
9Department of Pathology and Laboratory Medicine, New Jersey Medical School and Robert Wood Johnson Medical School, Rutgers University, Newark, NJ 08903, USA.
Eli L. Moss
10Department of Medicine and Genetics, Stanford University, Stanford, CA 94143, USA.
Shannon B. Falconer
10Department of Medicine and Genetics, Stanford University, Stanford, CA 94143, USA.
Ami S. Bhatt
10Department of Medicine and Genetics, Stanford University, Stanford, CA 94143, USA.
Ying Taur
2Weill Medical College of Cornell University, New York, NY 10065, USA.
11Infectious Disease Service, Lucille Castori Center for Microbes, Inflammation and Cancer, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Eric G. Pamer
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2Weill Medical College of Cornell University, New York, NY 10065, USA.
11Infectious Disease Service, Lucille Castori Center for Microbes, Inflammation and Cancer, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Marcel R. M. van den Brink
1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2Weill Medical College of Cornell University, New York, NY 10065, USA.
3Adult BMT (Bone Marrow Transplant) Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Robert R. Jenq
2Weill Medical College of Cornell University, New York, NY 10065, USA.
3Adult BMT (Bone Marrow Transplant) Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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