Research ArticleGraft-Versus-Host Disease

Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice

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Science Translational Medicine  18 May 2016:
Vol. 8, Issue 339, pp. 339ra71
DOI: 10.1126/scitranslmed.aaf2311

Article Information

vol. 8 no. 339 339ra71

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 12, 2016
  • Accepted for publication May 4, 2016
  • .

Author Information

  1. Yusuke Shono1,*,
  2. Melissa D. Docampo1,
  3. Jonathan U. Peled1,2,3,
  4. Suelen M. Perobelli1,
  5. Enrico Velardi1,4,
  6. Jennifer J. Tsai1,
  7. Ann E. Slingerland1,
  8. Odette M. Smith1,
  9. Lauren F. Young1,
  10. Jyotsna Gupta1,
  11. Sophia R. Lieberman1,
  12. Hillary V. Jay1,
  13. Katya F. Ahr1,
  14. Kori A. Porosnicu Rodriguez1,
  15. Ke Xu1,
  16. Marco Calarfiore1,
  17. Hendrik Poeck1,
  18. Silvia Caballero1,
  19. Sean M. Devlin5,
  20. Franck Rapaport6,
  21. Jarrod A. Dudakov1,7,
  22. Alan M. Hanash2,3,
  23. Boglarka Gyurkocza2,3,
  24. George F. Murphy8,
  25. Camilla Gomes8,
  26. Chen Liu9,
  27. Eli L. Moss10,
  28. Shannon B. Falconer10,
  29. Ami S. Bhatt10,
  30. Ying Taur2,11,
  31. Eric G. Pamer1,2,11,
  32. Marcel R. M. van den Brink1,2,3,*, and
  33. Robert R. Jenq2,3,*,
  1. 1Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  2. 2Weill Medical College of Cornell University, New York, NY 10065, USA.
  3. 3Adult BMT (Bone Marrow Transplant) Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  4. 4Department of Clinical and Experimental Medicine, University of Perugia, Perugia 06135, Italy.
  5. 5Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  6. 6Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  7. 7Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  8. 8Program in Dermatopathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  9. 9Department of Pathology and Laboratory Medicine, New Jersey Medical School and Robert Wood Johnson Medical School, Rutgers University, Newark, NJ 08903, USA.
  10. 10Department of Medicine and Genetics, Stanford University, Stanford, CA 94143, USA.
  11. 11Infectious Disease Service, Lucille Castori Center for Microbes, Inflammation and Cancer, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  1. *Corresponding author. Email: jenqr{at}mskcc.org (R.R.J.); shonoy{at}mskcc.org (Y.S.); vandenbm{at}mskcc.org (M.R.M.v.d.B)
    • These authors contributed equally to this work.

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