Research ArticleCancer

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

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Science Translational Medicine  18 May 2016:
Vol. 8, Issue 339, pp. 339ra69
DOI: 10.1126/scitranslmed.aad3099

Article Information

vol. 8 no. 339 339ra69

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 26, 2015
  • Accepted for publication April 4, 2016
  • .

Author Information

  1. Gabriela Brumatti1,2,*,
  2. Chunyan Ma1,2,*,
  3. Najoua Lalaoui1,2,
  4. Nhu-Y Nguyen3,
  5. Mario Navarro4,
  6. Maria C. Tanzer1,2,
  7. Jennifer Richmond5,
  8. Margherita Ghisi6,
  9. Jessica M. Salmon6,
  10. Natasha Silke1,2,
  11. Giovanna Pomilio3,
  12. Stefan P. Glaser1,2,
  13. Elisha de Valle7,8,
  14. Raffi Gugasyan7,8,
  15. Mark A. Gurthridge3,
  16. Stephen M. Condon9,
  17. Ricky W. Johnstone6,
  18. Richard Lock5,
  19. Guy Salvesen4,
  20. Andrew Wei3,
  21. David L. Vaux1,2,
  22. Paul G. Ekert1,2,10,, and
  23. John Silke1,2,,
  1. 1Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia.
  2. 2Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia.
  3. 3Alfred Hospital and Monash University, Melbourne, Victoria 3004, Australia.
  4. 4Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
  5. 5Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales 2031, Australia.
  6. 6Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.
  7. 7Burnet Institute, Melbourne, Victoria 3004, Australia.
  8. 8Department of Immunology, Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia.
  9. 9TetraLogic Pharmaceuticals Corporation, Malvern, PA 19355, USA.
  10. 10Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne, Victoria 3052, Australia.
  1. Corresponding author. Email: silke{at}wehi.edu.au (J.S.); paul.ekert{at}mcri.edu.au (P.G.E.)
    • * These authors contributed equally to this work.

    • These authors contributed equally to this work.

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