Research ArticleFertility

The prostaglandin transporter (PGT) as a potential mediator of ovulation

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Science Translational Medicine  11 May 2016:
Vol. 8, Issue 338, pp. 338ra68
DOI: 10.1126/scitranslmed.aad2709

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Prostaglandins are known to play an important role in ovulation, but the role of prostaglandin transporter, a protein that transports prostaglandins across the cell membrane, was not well understood. By studying the process of ovulation in human cells and in mouse models, Yerushalmi et al. found that the activity of the prostaglandin transporter regulates the extracellular concentration of prostaglandin E2 in the ovarian follicles and thereby determines whether ovulation will occur. The authors also showed that inhibiting this transporter blocks ovulation in mice, suggesting that this approach may be a feasible method of contraception if these results are confirmed in humans.

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