Research ArticleAlzheimer’s Disease

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

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Science Translational Medicine  11 May 2016:
Vol. 8, Issue 338, pp. 338ra66
DOI: 10.1126/scitranslmed.aaf2362

A window into Alzheimer’s disease

Alzheimer’s disease is pathologically defined by the accumulation of β-amyloid (Aβ) plaques and tau tangles. The cognitive and pathological correlates of Aβ deposition have been well studied owing to the availability of PET imaging ligands. Using newly available tau imaging agents, Brier et al. now explore relationships among tau pathology and Aβ with PET imaging, cerebrospinal fluid measures of disease, and cognition. Overall, tau imaging provided a more robust predictor of disease status than did Aβ imaging. Thus, whereas Aβ imaging provides a good marker for early disease state, tau imaging is a more robust predictor of disease progression.

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