Contents
11 May 2016
Vol 8, Issue 338
Vol 8, Issue 338
Contents
Editorial
- The need for global regulatory harmonization: A public health imperative
Because public health and innovation are no longer national issues, regulatory authorities must apply a global view to oversight.
Research Articles
- Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease
PET imaging of pathological tau correlates more closely with Alzheimer’s disease–related cognitive impairment than does imaging of β-amyloid.
- Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome
When heme synthesis exceeds globin synthesis, red blood cell differentiation fails, resulting in severe anemia.
- The prostaglandin transporter (PGT) as a potential mediator of ovulation
The prostaglandin transporter is a mediator of ovulation, and inhibiting it blocks ovulation in mice.
Editors' Choice
- Safely accelerating past stop signs
A screen of clinically safe compounds identifies drug candidates for cystic fibrosis treatment.
- Sex and the night shift
Under conditions mimicking jet lag or shift work, women were found to perform worse on cognitive tests compared to men.
- Metabolic dysfunction branches out
Amino acid metabolism is an important driver of heart failure and can be used for both diagnostic and therapeutic targeting in the failing heart.
- Collaborating tumor cells overcome multitargeted antiangiogenic therapies
Tumor cells make use of “metabolic symbiosis” to drive resistance to multitargeted angiogenesis inhibitors.
About The Cover
ONLINE COVER dHarmony. The world has a drug problem, but not the one you think. As symbolized by the mosaic map of medicines on today's cover, globalization has altered the landscape for discovery, regulation, and supply of pharmaceutical products. In this week's Editorial, Zerhouni and Hamburg discuss the need for global regulatory harmonization and begin to map out a solution that ultimately will orchestrate improvements in public health. [CREDIT: POGONICI/iSTOCKPHOTO.COM]