Contents

Contents

• Editorial

  • The need for global regulatory harmonization: A public health imperative

    By Elias Zerhouni, Margaret Hamburg

    Science Translational Medicine11 May 2016 : 338ed6 Full AccessRestricted Access

    Because public health and innovation are no longer national issues, regulatory authorities must apply a global view to oversight.

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• Research Articles

  • Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

    By Matthew R. Brier, Brian Gordon, Karl Friedrichsen, John McCarthy, Ari Stern, Jon Christensen, Christopher Owen, Patricia Aldea, Yi Su, Jason Hassenstab, Nigel J. Cairns, David M. Holtzman, Anne M. Fagan, John C. Morris, Tammie L. S. Benzinger, Beau M. Ances

    Science Translational Medicine11 May 2016 : 338ra66 Full AccessRestricted Access

    PET imaging of pathological tau correlates more closely with Alzheimer’s disease–related cognitive impairment than does imaging of β-amyloid.

    • Editor's Summary
    • Abstract
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  • Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome

    By Zhantao Yang, Siobán B. Keel, Akiko Shimamura, Li Liu, Aaron T. Gerds, Henry Y. Li, Brent L. Wood, Bart L. Scott, Janis L. Abkowitz

    Science Translational Medicine11 May 2016 : 338ra67 Full AccessRestricted Access

    When heme synthesis exceeds globin synthesis, red blood cell differentiation fails, resulting in severe anemia.

    • Editor's Summary
    • Abstract
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  • The prostaglandin transporter (PGT) as a potential mediator of ovulation

    By Gil M. Yerushalmi, Svetlana Markman, Yuval Yung, Ettie Maman, Sarit Aviel-Ronen, Raoul Orvieto, Eli Y. Adashi, Ariel Hourvitz

    Science Translational Medicine11 May 2016 : 338ra68 Full AccessRestricted Access

    The prostaglandin transporter is a mediator of ovulation, and inhibiting it blocks ovulation in mice.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • Safely accelerating past stop signs

    By Nirav R. Bhakta

    Science Translational Medicine11 May 2016 : 338ec74 Full AccessRestricted Access

    A screen of clinically safe compounds identifies drug candidates for cystic fibrosis treatment.

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  • Sex and the night shift

    By Brendan P. Lucey

    Science Translational Medicine11 May 2016 : 338ec75 Full AccessRestricted Access

    Under conditions mimicking jet lag or shift work, women were found to perform worse on cognitive tests compared to men.

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  • Metabolic dysfunction branches out

    By Katey J. Rayner

    Science Translational Medicine11 May 2016 : 338ec76 Full AccessRestricted Access

    Amino acid metabolism is an important driver of heart failure and can be used for both diagnostic and therapeutic targeting in the failing heart.

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  • Collaborating tumor cells overcome multitargeted antiangiogenic therapies

    By Kris C. Wood

    Science Translational Medicine11 May 2016 : 338ec77 Full AccessRestricted Access

    Tumor cells make use of “metabolic symbiosis” to drive resistance to multitargeted angiogenesis inhibitors.

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