Research ArticleFibrosis
Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis
- Kevin M. Vannella1,
- Thirumalai R. Ramalingam1,
- Lee A. Borthwick1,2,
- Luke Barron1,
- Kevin M. Hart1,
- Robert W. Thompson1,
- Kristen N. Kindrachuk1,
- Allen W. Cheever1,3,
- Sandra White1,
- Alison L. Budelsky4,
- Michael R. Comeau4,
- Dirk E. Smith4 and
- Thomas A. Wynn1,*
- 1Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 2Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
- 3Biomedical Research Institute, Rockville, MD 20852, USA.
- 4Department of Inflammation Research, Amgen, 1201 Amgen Court West, Seattle, WA 98119, USA.
- ↵*Corresponding author. Email: twynn{at}niaid.nih.gov
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Science Translational Medicine 04 May 2016:
Vol. 8, Issue 337, pp. 337ra65
DOI: 10.1126/scitranslmed.aaf1938
Vol. 8, Issue 337, pp. 337ra65
DOI: 10.1126/scitranslmed.aaf1938
Kevin M. Vannella
1Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Thirumalai R. Ramalingam
1Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Lee A. Borthwick
1Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
2Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Luke Barron
1Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Kevin M. Hart
1Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Robert W. Thompson
1Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Kristen N. Kindrachuk
1Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Allen W. Cheever
1Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
3Biomedical Research Institute, Rockville, MD 20852, USA.
Sandra White
1Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Alison L. Budelsky
4Department of Inflammation Research, Amgen, 1201 Amgen Court West, Seattle, WA 98119, USA.
Michael R. Comeau
4Department of Inflammation Research, Amgen, 1201 Amgen Court West, Seattle, WA 98119, USA.
Dirk E. Smith
4Department of Inflammation Research, Amgen, 1201 Amgen Court West, Seattle, WA 98119, USA.
Thomas A. Wynn
1Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
