Research ArticleHIV

Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages

See allHide authors and affiliations

Science Translational Medicine  27 Apr 2016:
Vol. 8, Issue 336, pp. 336ra62
DOI: 10.1126/scitranslmed.aaf0618

An immune block to HIV vaccines

Because HIV is a rapidly mutating virus, a successful vaccine will need to elicit an immune response against a variety of HIV strains—broadly neutralizing antibodies (bnAbs). However, despite multiple promising targets, bnAb generation after HIV vaccination has remained elusive. Now, Zhang et al. report that bnAbs to one such target, gp41, are controlled by immune tolerance. In mouse and macaque, precursors to these antibodies are either deleted or do not attain sufficient affinity to neutralize virus. Therefore, a successful vaccine for HIV will need to overcome immune tolerance mechanisms.

View Full Text

Stay Connected to Science Translational Medicine