Contents
27 April 2016
Vol 8, Issue 336
Vol 8, Issue 336
Contents
Editorial
- An incentive-based approach for improving data reproducibility
A scientist who has worked in both academia and industry offers an incentive-based and nonprescriptive proposal to reduce data irreproducibility.
Perspective
- On the path to a science of patient input
No longer is patient engagement the fanciful notion it was at the start of FasterCures’ journey in 2003, and the rush of activity is welcome and vital.
Research Articles
- IRF7 inhibition prevents destructive innate immunity—A target for nonantibiotic therapy of bacterial infections
Interferon regulatory factor 7 is an innate immune target for non–antibiotic-based immunotherapy for bacterial infection.
- ZP2 peptide beads select human sperm in vitro, decoy mouse sperm in vivo, and provide reversible contraception
Sperm bind to ZP2 peptide beads, which can select superior sperm for assisted reproduction but can also be used for contraception.
- MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome
The MDM2 inhibitor Nutlin-3 rescues neurogenic and cognitive deficits in mice with fragile X syndrome.
- Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages
Immune tolerance mechanisms limit gp41 neutralizing antibody lineage maturation to broadly neutralizing antibodies.
Editors' Choice
- Diabetes: The roles of brains, brawn, and brown fat?
A central nervous system circuit regulating brown fat function and gene expression may play a role in the development of insulin resistance.
- Worth more than the paper it’s written on
Simple, low-cost diagnostic tool reliably measures respiration rate using graphite ink and common laboratory paper.
- Do as the pathogens do
New bacteria-inspired design of a vaccine-adjuvant delivery system leads to enhanced immune responses.
- A one-two punch for pain control
A silica nanoparticle delivery system provides sustained pain relief in mice by combining an anesthetic with a tissue-protecting peptide.
Podcast
- Science Translational Medicine Podcast: 27 April 2016
Peptide-coated beads could be used for contraception or to select the sperm best suited for use in assisted reproduction.
About The Cover
ONLINE COVER New Field Takes Flight. The origami cranes on this week's cover had to be carefully constructed before they could spread their wings and soar. In contrast, stakeholders are fashioning a new field of patient input that has already begun to take flight. In this week's Perspective, Anderson and McCleary discuss ways of leveraging available resources and develop a baseline assessment for measuring the field's growth and identifying areas of unmet need. [CREDIT: VERA KONTRIKOVA/ALAMY STOCK PHOTO]