Research ArticleMetabolism
Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females
- Vicent Ribas1,*,
- Brian G. Drew1,*,
- Zhenqi Zhou1,*,
- Jennifer Phun1,
- Nareg Y. Kalajian1,
- Teo Soleymani1,
- Pedram Daraei1,
- Kevin Widjaja1,
- Jonathan Wanagat2,
- Thomas Q. de Aguiar Vallim3,
- Amy H. Fluitt1,4,
- Steven Bensinger4,
- Thuc Le4,5,
- Caius Radu4,5,
- Julian P. Whitelegge6,
- Simon W. Beaven7,
- Peter Tontonoz7,
- Aldons J. Lusis3,8,
- Brian W. Parks8,
- Laurent Vergnes8,
- Karen Reue8,
- Harpreet Singh9,
- Jean C. Bopassa9,
- Ligia Toro9,
- Enrico Stefani9,
- Matthew J. Watt10,
- Simon Schenk11,
- Thorbjorn Akerstrom12,
- Meghan Kelly12,†,
- Bente K. Pedersen12,
- Sylvia C. Hewitt13,
- Kenneth S. Korach13 and
- Andrea L. Hevener1,14,‡
- 1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
- 2Division of Geriatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 3Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 4Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 5Ahmanson Translational Imaging Division, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 6Pasarow Mass Spectrometry Laboratory and Neuropsychiatric Institute–Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 7Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 8Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 9Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
- 10Department of Physiology, Monash University, Clayton, Victoria 3800, Australia.
- 11Department of Orthopaedic Surgery, University of California, San Diego, La Jolla, CA 92093, USA.
- 12Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2200, Denmark.
- 13Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC 27709, USA.
- 14UCLA Iris Cantor Women’s Health Research Center, Los Angeles, CA 90095, USA.
- ↵‡Corresponding author. E-mail: ahevener{at}mednet.ucla.edu
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Science Translational Medicine 13 Apr 2016:
Vol. 8, Issue 334, pp. 334ra54
DOI: 10.1126/scitranslmed.aad3815
Vol. 8, Issue 334, pp. 334ra54
DOI: 10.1126/scitranslmed.aad3815
Vicent Ribas
1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Brian G. Drew
1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Zhenqi Zhou
1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Jennifer Phun
1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Nareg Y. Kalajian
1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Teo Soleymani
1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Pedram Daraei
1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Kevin Widjaja
1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Jonathan Wanagat
2Division of Geriatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Thomas Q. de Aguiar Vallim
3Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Amy H. Fluitt
1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
4Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Steven Bensinger
4Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Thuc Le
4Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
5Ahmanson Translational Imaging Division, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Caius Radu
4Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
5Ahmanson Translational Imaging Division, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Julian P. Whitelegge
6Pasarow Mass Spectrometry Laboratory and Neuropsychiatric Institute–Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Simon W. Beaven
7Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Peter Tontonoz
7Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Aldons J. Lusis
3Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
8Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Brian W. Parks
8Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Laurent Vergnes
8Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Karen Reue
8Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Harpreet Singh
9Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Jean C. Bopassa
9Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Ligia Toro
9Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Enrico Stefani
9Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Matthew J. Watt
10Department of Physiology, Monash University, Clayton, Victoria 3800, Australia.
Simon Schenk
11Department of Orthopaedic Surgery, University of California, San Diego, La Jolla, CA 92093, USA.
Thorbjorn Akerstrom
12Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2200, Denmark.
Meghan Kelly
12Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2200, Denmark.
Bente K. Pedersen
12Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2200, Denmark.
Sylvia C. Hewitt
13Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC 27709, USA.
Kenneth S. Korach
13Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC 27709, USA.
Andrea L. Hevener
1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
14UCLA Iris Cantor Women’s Health Research Center, Los Angeles, CA 90095, USA.
