The Human Vaccines Project: A roadmap for cancer vaccine development

Pedro Romero; Jacques Banchereau; Nina Bhardwaj; Mark Cockett; Mary L. Disis; Glenn Dranoff; Eli Gilboa; Scott A. Hammond; Robert Hershberg; Alan J. Korman; Pia Kvistborg; Cornelis Melief; Ira Mellman; A. Karolina Palucka; Irina Redchenko; Harlan Robins; Federica Sallusto; Theodore Schenkelberg; Stephen Schoenberger; Jeffrey Sosman; Özlem Türeci; Benoît Van den Eynde; Wayne Koff; George Coukos

doi:10.1126/scitranslmed.aaf0685

PerspectiveCancer

The Human Vaccines Project: A roadmap for cancer vaccine development

Pedro Romero¹,
Jacques Banchereau²,
Nina Bhardwaj³,
Mark Cockett⁴,*,
Mary L. Disis⁵,
Glenn Dranoff⁶,
Eli Gilboa⁷,
Scott A. Hammond⁸,
Robert Hershberg⁹,
Alan J. Korman¹⁰,
Pia Kvistborg¹¹,
Cornelis Melief¹²,
Ira Mellman¹³,
A. Karolina Palucka²,¹⁴,
Irina Redchenko¹⁵,
Harlan Robins¹⁶,
Federica Sallusto¹⁷,
Theodore Schenkelberg¹⁸,
Stephen Schoenberger¹⁹,
Jeffrey Sosman²⁰,
Özlem Türeci²¹,
Benoît Van den Eynde²²,²³,²⁴,
Wayne Koff²⁵ and
George Coukos¹,†

¹Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland.
²The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
³Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
⁴Bristol-Myers Squibb, Wallingford, CT06492, USA.
⁵University of Washington School of Medicine, Seattle, WA 98109-4714, USA.
⁶Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
⁷Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
⁸MedImmune, Gaithersburg, MD 20878, USA.
⁹Celgene Immuno-Oncology Center of Excellence, 1616 Eastlake Avenue, Suite 500, Seattle, WA 98102, USA.
¹⁰Bristol-Myers Squibb, Biologics Discovery California, Redwood City, CA 94063, USA.
¹¹Netherlands Cancer Institute, 1066CX Amsterdam, Netherlands.
¹²ISA Pharmaceuticals & Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
¹³Genentech, San Francisco, CA 94080, USA.
¹⁴Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
¹⁵Oxford University, Oxford OX3 7DQ, UK.
¹⁶Adaptive Biotechnologies, Fred Hutchinson Cancer Research Center, Seattle, WA 98102, USA.
¹⁷Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
¹⁸West Monument Consulting, 1906 R Street NW Street 11, Washington, DC 20009, USA.
¹⁹Center for Personalized Cancer Immunotherapy, La Jolla Institute for Allergy and Immunology & UCSD Moores Cancer Center, La Jolla, San Diego, CA 92037, USA.
²⁰Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA.
²¹CI3 Cluster for Individualized Immunotherapy, Kupferbergterasse 17-19, 55131 Mainz, Germany.
²²Ludwig Institute for Cancer Research, Brussels branch, Brussels, BRU 1200, Belgium.
²³Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Woluwe-Saint-Lambert, Belgium.
²⁴University of Oxford, Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
²⁵International AIDS Vaccines Initiative, 125 Broad Street, 9th Floor, New York, NY 10004, USA.

↵†Corresponding author. E-mail: george.coukos{at}chuv.ch

↵* Present address: ViiV Healthcare, 5 Research Parkway, Wallingford, CT 06492, USA.

See allHide authors and affiliations

Science Translational Medicine 13 Apr 2016:
Vol. 8, Issue 334, pp. 334ps9
DOI: 10.1126/scitranslmed.aaf0685

Pedro Romero

1Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jacques Banchereau

2The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nina Bhardwaj

3Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mark Cockett

4Bristol-Myers Squibb, Wallingford, CT06492, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mary L. Disis

5University of Washington School of Medicine, Seattle, WA 98109-4714, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Glenn Dranoff

6Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Eli Gilboa

7Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Scott A. Hammond

8MedImmune, Gaithersburg, MD 20878, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Robert Hershberg

9Celgene Immuno-Oncology Center of Excellence, 1616 Eastlake Avenue, Suite 500, Seattle, WA 98102, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alan J. Korman

10Bristol-Myers Squibb, Biologics Discovery California, Redwood City, CA 94063, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Pia Kvistborg

11Netherlands Cancer Institute, 1066CX Amsterdam, Netherlands.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Cornelis Melief

12ISA Pharmaceuticals & Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ira Mellman

13Genentech, San Francisco, CA 94080, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

A. Karolina Palucka

2The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.

14Baylor Institute for Immunology Research, Dallas, TX 75204, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Irina Redchenko

15Oxford University, Oxford OX3 7DQ, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Harlan Robins

16Adaptive Biotechnologies, Fred Hutchinson Cancer Research Center, Seattle, WA 98102, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Federica Sallusto

17Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Theodore Schenkelberg

18West Monument Consulting, 1906 R Street NW Street 11, Washington, DC 20009, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Stephen Schoenberger

19Center for Personalized Cancer Immunotherapy, La Jolla Institute for Allergy and Immunology & UCSD Moores Cancer Center, La Jolla, San Diego, CA 92037, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jeffrey Sosman

20Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Özlem Türeci

21CI3 Cluster for Individualized Immunotherapy, Kupferbergterasse 17-19, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Benoît Van den Eynde

22Ludwig Institute for Cancer Research, Brussels branch, Brussels, BRU 1200, Belgium.

23Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Woluwe-Saint-Lambert, Belgium.

24University of Oxford, Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Wayne Koff

25International AIDS Vaccines Initiative, 125 Broad Street, 9th Floor, New York, NY 10004, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

George Coukos

1Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: george.coukos@chuv.ch

Article
Figures & Data
Info & Metrics
eLetters
PDF

You are currently viewing the abstract.

View Full Text

Log in to view the full text

via AAAS login

AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.

Become an AAAS Member
Activate your Account
Purchase Access to Other Journals in the Science Family
Account Help

Log in through your institution

More options

Purchase digital access to this article

Download and print this article for your personal scholarly, research, and educational use.

Purchase this issue in print

Buy a single issue of Science for just $15 USD.

Abstract

Cancer vaccine development has been vigorously pursued for 40 years. Immunity to tumor antigens can be elicited by most vaccines tested, but their clinical efficacy remains modest. We argue that a concerted international effort is necessary to understand the human antitumor immune response and achieve clinically effective cancer vaccines.

View Full Text

The Human Vaccines Project: A roadmap for cancer vaccine development

Abstract

Science Translational Medicine

Article Tools