The Human Vaccines Project: A roadmap for cancer vaccine development

Pedro Romero; Jacques Banchereau; Nina Bhardwaj; Mark Cockett; Mary L. Disis; Glenn Dranoff; Eli Gilboa; Scott A. Hammond; Robert Hershberg; Alan J. Korman; Pia Kvistborg; Cornelis Melief; Ira Mellman; A. Karolina Palucka; Irina Redchenko; Harlan Robins; Federica Sallusto; Theodore Schenkelberg; Stephen Schoenberger; Jeffrey Sosman; Özlem Türeci; Benoît Van den Eynde; Wayne Koff; George Coukos

doi:10.1126/scitranslmed.aaf0685

PerspectiveCancer

The Human Vaccines Project: A roadmap for cancer vaccine development

Pedro Romero¹,
Jacques Banchereau²,
Nina Bhardwaj³,
Mark Cockett⁴,*,
Mary L. Disis⁵,
Glenn Dranoff⁶,
Eli Gilboa⁷,
Scott A. Hammond⁸,
Robert Hershberg⁹,
Alan J. Korman¹⁰,
Pia Kvistborg¹¹,
Cornelis Melief¹²,
Ira Mellman¹³,
A. Karolina Palucka²,¹⁴,
Irina Redchenko¹⁵,
Harlan Robins¹⁶,
Federica Sallusto¹⁷,
Theodore Schenkelberg¹⁸,
Stephen Schoenberger¹⁹,
Jeffrey Sosman²⁰,
Özlem Türeci²¹,
Benoît Van den Eynde²²,²³,²⁴,
Wayne Koff²⁵ and
George Coukos¹,†

¹Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland.
²The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
³Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
⁴Bristol-Myers Squibb, Wallingford, CT06492, USA.
⁵University of Washington School of Medicine, Seattle, WA 98109-4714, USA.
⁶Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
⁷Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
⁸MedImmune, Gaithersburg, MD 20878, USA.
⁹Celgene Immuno-Oncology Center of Excellence, 1616 Eastlake Avenue, Suite 500, Seattle, WA 98102, USA.
¹⁰Bristol-Myers Squibb, Biologics Discovery California, Redwood City, CA 94063, USA.
¹¹Netherlands Cancer Institute, 1066CX Amsterdam, Netherlands.
¹²ISA Pharmaceuticals & Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
¹³Genentech, San Francisco, CA 94080, USA.
¹⁴Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
¹⁵Oxford University, Oxford OX3 7DQ, UK.
¹⁶Adaptive Biotechnologies, Fred Hutchinson Cancer Research Center, Seattle, WA 98102, USA.
¹⁷Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
¹⁸West Monument Consulting, 1906 R Street NW Street 11, Washington, DC 20009, USA.
¹⁹Center for Personalized Cancer Immunotherapy, La Jolla Institute for Allergy and Immunology & UCSD Moores Cancer Center, La Jolla, San Diego, CA 92037, USA.
²⁰Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA.
²¹CI3 Cluster for Individualized Immunotherapy, Kupferbergterasse 17-19, 55131 Mainz, Germany.
²²Ludwig Institute for Cancer Research, Brussels branch, Brussels, BRU 1200, Belgium.
²³Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Woluwe-Saint-Lambert, Belgium.
²⁴University of Oxford, Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
²⁵International AIDS Vaccines Initiative, 125 Broad Street, 9th Floor, New York, NY 10004, USA.

↵†Corresponding author. E-mail: george.coukos{at}chuv.ch

↵* Present address: ViiV Healthcare, 5 Research Parkway, Wallingford, CT 06492, USA.

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Science Translational Medicine 13 Apr 2016:
Vol. 8, Issue 334, pp. 334ps9
DOI: 10.1126/scitranslmed.aaf0685

Pedro Romero

Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland.

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Jacques Banchereau

The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.

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Nina Bhardwaj

Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Mark Cockett

Bristol-Myers Squibb, Wallingford, CT06492, USA.

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Mary L. Disis

University of Washington School of Medicine, Seattle, WA 98109-4714, USA.

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Glenn Dranoff

Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.

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Eli Gilboa

Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.

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Scott A. Hammond

MedImmune, Gaithersburg, MD 20878, USA.

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Robert Hershberg

Celgene Immuno-Oncology Center of Excellence, 1616 Eastlake Avenue, Suite 500, Seattle, WA 98102, USA.

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Alan J. Korman

Bristol-Myers Squibb, Biologics Discovery California, Redwood City, CA 94063, USA.

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Pia Kvistborg

Netherlands Cancer Institute, 1066CX Amsterdam, Netherlands.

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Cornelis Melief

ISA Pharmaceuticals & Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

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Ira Mellman

Genentech, San Francisco, CA 94080, USA.

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A. Karolina Palucka

The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.Baylor Institute for Immunology Research, Dallas, TX 75204, USA.

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Irina Redchenko

Oxford University, Oxford OX3 7DQ, UK.

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Harlan Robins

Adaptive Biotechnologies, Fred Hutchinson Cancer Research Center, Seattle, WA 98102, USA.

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Federica Sallusto

Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.

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Theodore Schenkelberg

West Monument Consulting, 1906 R Street NW Street 11, Washington, DC 20009, USA.

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Stephen Schoenberger

Center for Personalized Cancer Immunotherapy, La Jolla Institute for Allergy and Immunology & UCSD Moores Cancer Center, La Jolla, San Diego, CA 92037, USA.

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Jeffrey Sosman

Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA.

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Özlem Türeci

CI3 Cluster for Individualized Immunotherapy, Kupferbergterasse 17-19, 55131 Mainz, Germany.

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Benoît Van den Eynde

Ludwig Institute for Cancer Research, Brussels branch, Brussels, BRU 1200, Belgium.Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Woluwe-Saint-Lambert, Belgium.University of Oxford, Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

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Wayne Koff

International AIDS Vaccines Initiative, 125 Broad Street, 9th Floor, New York, NY 10004, USA.

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George Coukos

Ludwig Cancer Research at University of Lausanne, 1066 Epalinges, Switzerland.

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For correspondence: george.coukos@chuv.ch

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Abstract

Cancer vaccine development has been vigorously pursued for 40 years. Immunity to tumor antigens can be elicited by most vaccines tested, but their clinical efficacy remains modest. We argue that a concerted international effort is necessary to understand the human antitumor immune response and achieve clinically effective cancer vaccines.

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The Human Vaccines Project: A roadmap for cancer vaccine development

Abstract

Science Translational Medicine

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