Contents
13 April 2016
Vol 8, Issue 334
Vol 8, Issue 334
Contents
Editorial
- Global health partnerships: Are they working?
An assessment of global health collaborations highlights the advantages of synergies between global health research and training programs.
Perspective
- The Human Vaccines Project: A roadmap for cancer vaccine development
A concerted international effort is necessary to achieve clinically effective cancer vaccines.
Research Articles
- NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis
Antioxidant antidiabetic drugs may promote tumor metastasis.
- Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses
Therapeutic vaccination against HPV16 is effective with chemotherapy for advanced cervical cancer patients.
- Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence
JAK2 amplification decreases survival in triple-negative breast cancer but can be targeted with JAK2-specific inhibitors.
- Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females
ERα action in skeletal muscle is involved in the preservation of mitochondrial health and insulin sensitivity in female mice and can serve as a defense against metabolic disease in women.
Editors' Choice
- I heart lymphatics
The build-up of fluid after a heart attack is linked to cardiac lymphatic insufficiency, which can be reversed to halt fibrosis and dysfunction.
- H5N1 stems the alveolar tide: MSCs to the rescue!
Injection of mesenchymal stromal cells increased survival in murine H5N1 influenza pneumonia by improving alveolar fluid clearance.
- Can the past predict the future?
Maternal immune activation may induce transgenerational transmission of behavioral defects.
- CoINcIDE: All together now
Meta-analysis for unsupervised clustering of clinical data empowers scientists to use small data sets for patient subtype discovery.
About The Cover
ONLINE COVER Starring Role for JAK2. This image shows triple-negative breast cancer cells with amplification at 9p24, the site of the JAK2 gene. The centromere of chromosome 9 is green, and orange marks the 9p24 locus. In the current issue, Balko et al. show that JAK2 is amplified in these aggressive breast tumors and that it can be targeted with a JAK2-specific inhibitor. To coincide with the annual meeting of the American Association for Cancer Research, this issue also includes several other cancer articles: Wang et al. report that antioxidant drugs for diabetes may increase the risk of metastasis in patients with cancer, Welters and colleagues present an effective way to combine a therapeutic vaccine with chemotherapy for cervical cancer, and Romero et al. discuss an international effort to accelerate the development of cancer vaccines. [CREDIT: JENNIFER GILTNAME, VANDERBILT UNIVERSITY]