Contents
06 April 2016
Vol 8, Issue 333
Vol 8, Issue 333
Contents
Perspective
- A “datathon” model to support cross-disciplinary collaboration
A “datathon” model combines complementary knowledge and skills to formulate inquiries and drive research that addresses information gaps faced by clinicians.
Research Articles
- Androgen receptor antagonists compromise T cell response against prostate cancer leading to early tumor relapse
Chemical androgen deprivation therapy may suppress adaptive immune responses and block the efficacy of immunotherapy.
- Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity
A method to culture human cortical neurons that yielded a balanced network of excitatory and inhibitory neurons revealed that these cells die in a PARP-dependent manner after neurotoxic insult.
- Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform
Postoperative liver transplant immunosuppression was personalized using a phenotypic, disease mechanism–independent and indication-agnostic approach.
- Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
The cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin facilitates atheroprotective mechanisms through oxysterol-mediated reprogramming of macrophages.
Editors' Choice
- Poster child: Ready for a close-up
Resistance to PD1 inhibitors in melanoma is associated with a unique transcriptomic signature.
- Desferrioxamine passes the sniff test
An iron chelator delivered through the nose prevented neurodegeneration in a rodent model of Parkinson’s disease.
- Rhythm fuels the adipose tissue fire
Circadian utilization of glucose by human brown adipose tissue affects thermogenesis.
- Cancer metastases: Are one and all the same?
Most known tumor driver mutations and resistance mechanisms in metastatic prostate cancer are shared, suggesting that a single biopsy may be clinically representative of other dispersed metastases in a given patient.
About The Cover
ONLINE COVER Personalized Dosing. Keeping track of drug doses for patients on complicated regimens is no trivial task. To limit the educated guesswork and impart tighter control over the effects of multiple drugs, Zarrinpar and colleagues devised a mathematical approach that used drug concentration as an input and trough level in the blood as the output. The authors compared their equation against standard physician-guided care in a pilot study of eight patients who were on immunosuppressants after liver transplants. [CREDIT: Zarrinpar et al., SCIENCE TRANSLATIONAL MEDICINE]