Research ArticleInflammation
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
- Seth L. Masters1,2,*,
- Vasiliki Lagou3,4,5,†,
- Isabelle Jéru6,7,8,†,
- Paul J. Baker1,2,†,
- Lien Van Eyck4,5,
- David A. Parry9,
- Dylan Lawless10,
- Dominic De Nardo1,2,
- Josselyn E. Garcia-Perez4,5,
- Laura F. Dagley1,2,11,
- Caroline L. Holley12,
- James Dooley4,5,
- Fiona Moghaddas1,2,
- Emanuela Pasciuto4,5,
- Pierre-Yves Jeandel13,
- Raf Sciot14,15,
- Dena Lyras16,
- Andrew I. Webb2,11,
- Sandra E. Nicholson1,2,
- Lien De Somer15,
- Erika van Nieuwenhove4,5,15,
- Julia Ruuth-Praz7,8,
- Bruno Copin8,
- Emmanuelle Cochet8,
- Myrna Medlej-Hashim17,
- Andre Megarbane18,
- Kate Schroder12,
- Sinisa Savic19,20,
- An Goris3,
- Serge Amselem6,7,8,
- Carine Wouters4,15,*,‡ and
- Adrian Liston4,5,*,‡
- 1Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3052, Australia.
- 2Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
- 3Department of Neurosciences, KU Leuven, Leuven 3000, Belgium.
- 4Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.
- 5Translational Immunology Laboratory, VIB, Leuven 3000, Belgium.
- 6INSERM, UMR S933, Paris F-75012, France.
- 7Université Pierre et Marie Curie–Paris, UMR S933, Paris F-75012, France.
- 8Assistance Publique Hôpitaux de Paris, Hôpital Trousseau, Service de Génétique et d’Embryologie médicales, Paris F-75012, France.
- 9Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh LS7 4SA, UK.
- 10Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Wellcome Trust Brenner Building, Saint James’s University Hospital, Leeds LS7 4SA, UK.
- 11Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
- 12Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, Brisbane, Queensland 4072, Australia.
- 13Département de Médecine Interne, Hôpital Archet 1, Université Nice Sophia-Antipolis, 06202 Nice, France.
- 14Department of Pathology, KU Leuven, Leuven 3000, Belgium.
- 15University Hospitals Leuven, Leuven 3000, Belgium.
- 16Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia.
- 17Department of Life and Earth Sciences, Faculty of Sciences II, Lebanese University, Beirut 1102 2801, Lebanon.
- 18Al-Jawhara Center, Arabian Gulf University, Manama 26671, Bahrain.
- 19Department of Allergy and Clinical Immunology, Saint James’s University Hospital, Leeds LS9 7TF, UK.
- 20National Institute for Health Research–Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, Wellcome Trust Brenner Building, Saint James’s University Hospital, Beckett Street, Leeds LS9 7TF, UK.
- ↵*Corresponding author. E-mail: masters{at}wehi.edu.au (S.L.M.); carine.wouters{at}uzleuven.be (C.W.); adrian.liston{at}vib.be (A.L.)
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Science Translational Medicine 30 Mar 2016:
Vol. 8, Issue 332, pp. 332ra45
DOI: 10.1126/scitranslmed.aaf1471
Vol. 8, Issue 332, pp. 332ra45
DOI: 10.1126/scitranslmed.aaf1471
Seth L. Masters
Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3052, Australia.Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Vasiliki Lagou
Department of Neurosciences, KU Leuven, Leuven 3000, Belgium.Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.Translational Immunology Laboratory, VIB, Leuven 3000, Belgium.
Isabelle Jéru
INSERM, UMR S933, Paris F-75012, France.Université Pierre et Marie Curie–Paris, UMR S933, Paris F-75012, France.Assistance Publique Hôpitaux de Paris, Hôpital Trousseau, Service de Génétique et d’Embryologie médicales, Paris F-75012, France.
Paul J. Baker
Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3052, Australia.Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Lien Van Eyck
Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.Translational Immunology Laboratory, VIB, Leuven 3000, Belgium.
David A. Parry
Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh LS7 4SA, UK.
Dylan Lawless
Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Wellcome Trust Brenner Building, Saint James’s University Hospital, Leeds LS7 4SA, UK.
Dominic De Nardo
Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3052, Australia.Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Josselyn E. Garcia-Perez
Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.Translational Immunology Laboratory, VIB, Leuven 3000, Belgium.
Laura F. Dagley
Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3052, Australia.Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
Caroline L. Holley
Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, Brisbane, Queensland 4072, Australia.
James Dooley
Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.Translational Immunology Laboratory, VIB, Leuven 3000, Belgium.
Fiona Moghaddas
Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3052, Australia.Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Emanuela Pasciuto
Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.Translational Immunology Laboratory, VIB, Leuven 3000, Belgium.
Pierre-Yves Jeandel
Département de Médecine Interne, Hôpital Archet 1, Université Nice Sophia-Antipolis, 06202 Nice, France.
Raf Sciot
Department of Pathology, KU Leuven, Leuven 3000, Belgium.University Hospitals Leuven, Leuven 3000, Belgium.
Dena Lyras
Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia.
Andrew I. Webb
Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
Sandra E. Nicholson
Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3052, Australia.Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Lien De Somer
University Hospitals Leuven, Leuven 3000, Belgium.
Erika van Nieuwenhove
Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.Translational Immunology Laboratory, VIB, Leuven 3000, Belgium.University Hospitals Leuven, Leuven 3000, Belgium.
Julia Ruuth-Praz
Université Pierre et Marie Curie–Paris, UMR S933, Paris F-75012, France.Assistance Publique Hôpitaux de Paris, Hôpital Trousseau, Service de Génétique et d’Embryologie médicales, Paris F-75012, France.
Bruno Copin
Assistance Publique Hôpitaux de Paris, Hôpital Trousseau, Service de Génétique et d’Embryologie médicales, Paris F-75012, France.
Emmanuelle Cochet
Assistance Publique Hôpitaux de Paris, Hôpital Trousseau, Service de Génétique et d’Embryologie médicales, Paris F-75012, France.
Myrna Medlej-Hashim
Department of Life and Earth Sciences, Faculty of Sciences II, Lebanese University, Beirut 1102 2801, Lebanon.
Andre Megarbane
Al-Jawhara Center, Arabian Gulf University, Manama 26671, Bahrain.
Kate Schroder
Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, Brisbane, Queensland 4072, Australia.
Sinisa Savic
Department of Allergy and Clinical Immunology, Saint James’s University Hospital, Leeds LS9 7TF, UK.National Institute for Health Research–Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, Wellcome Trust Brenner Building, Saint James’s University Hospital, Beckett Street, Leeds LS9 7TF, UK.
An Goris
Department of Neurosciences, KU Leuven, Leuven 3000, Belgium.
Serge Amselem
INSERM, UMR S933, Paris F-75012, France.Université Pierre et Marie Curie–Paris, UMR S933, Paris F-75012, France.Assistance Publique Hôpitaux de Paris, Hôpital Trousseau, Service de Génétique et d’Embryologie médicales, Paris F-75012, France.
Carine Wouters
Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.University Hospitals Leuven, Leuven 3000, Belgium.
Adrian Liston
Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.Translational Immunology Laboratory, VIB, Leuven 3000, Belgium.
